EFFECT OF P-CHLOROPHENYLALANINE AND ALPHA-METHYLTYROSINE ON THE ANTINOCICEPTIVE EFFECT OF ANTIDEPRESSANT DRUGS

被引:31
作者
SIERRALTA, F [1 ]
PINARDI, G [1 ]
MIRANDA, HF [1 ]
机构
[1] UNIV CHILE,FAC MED,DEPT EXPTL MED,SANTIAGO 7,CHILE
来源
PHARMACOLOGY & TOXICOLOGY | 1995年 / 77卷 / 04期
关键词
D O I
10.1111/j.1600-0773.1995.tb01027.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The role of para-chlorophenylalanine and alpha-methyl-DL-p-tyrosine in the antinociceptive effects of the intracerebroventricular administration of the antidepressant drugs clomipramine, zimelidine, imipramine and maprotiline was studied using the acetic acid writhing test in mice. The results demonstrated an antinociceptive effect for all these antidepressants. Pretreatment with para-chlorophenylalanine significantly reduced the antinociception induced by the ED(50)'s of imipramine and maprotiline, and did not modify the effects of zimelidine and clomipramine, pretreatment with alpha-methyltyrosine did not modify the antinociception induced by these drugs except maprotiline. Pretreatment with para-chlorophenylanine plus alpha-methyltyrosine significantly reduced the antinociceptive effect of all the antidepressants tested. The main finding of the present study is that the association of para-chlorophenylanine plus alpha-methyltyrosine reduced the antinociceptive action of all the antidepressants. This means that critical levels of both 5-HT and NA are responsible for mediating the antinociceptive effects of antidepressants on the writhing test in mice.
引用
收藏
页码:276 / 280
页数:5
相关论文
共 48 条
[41]   THE ANALGESIC EFFECT OF TRICYCLIC ANTIDEPRESSANTS [J].
TURA, B ;
TURA, SM .
BRAIN RESEARCH, 1990, 518 (1-2) :19-22
[42]   A CLASSIFICATION OF OPIATE RECEPTORS THAT MEDIATE ANTINOCICEPTION IN ANIMALS [J].
TYERS, MB .
BRITISH JOURNAL OF PHARMACOLOGY, 1980, 69 (03) :503-512
[43]   ANTINOCICEPTIVE EFFECTS OF TRAZODONE AND M-CHLOROPHENYLPIPERAZINE (MCPP) IN MICE - INTERACTION WITH MORPHINE [J].
VALERI, P ;
PIMPINELLA, G ;
MORRONE, LA ;
ROMANELLI, L .
GENERAL PHARMACOLOGY, 1991, 22 (01) :127-131
[44]   IN SEARCH OF THE MODE OF ACTION OF ANTI-DEPRESSANTS - 5-HTP TYROSINE MIXTURES IN DEPRESSIONS [J].
VANPRAAG, HM .
NEUROPHARMACOLOGY, 1983, 22 :433-440
[45]   EFFECT OF LOWERING 5-HYDROXYTRYPTAMINE CONTENT OF RAT SPINAL-CORD ON ANALGESIA PRODUCED BY MORPHINE [J].
VOGT, M .
JOURNAL OF PHYSIOLOGY-LONDON, 1974, 236 (02) :483-498
[46]  
WARD SJ, 1983, J PHARMACOL EXP THER, V224, P525
[47]   NALOXONE CAUSES APPARENT ANTINOCICEPTION AND PRONOCICEPTION SIMULTANEOUSLY IN THE RAT PAW FORMALIN TEST [J].
WHEELERACETO, H ;
COWAN, A .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1993, 236 (02) :193-199
[48]  
1983, PAIN, V16, P109