[H-3] PRAZOSIN BINDING IN THE INTERMEDIOLATERAL CELL COLUMN AND THE EFFECTS OF IONTOPHORESED METHOXAMINE ON SYMPATHETIC PREGANGLIONIC NEURONAL-ACTIVITY IN THE ANESTHETIZED CAT AND RAT

被引：21

作者：

MARKS, SA ^{[1
]}

STEIN, RD ^{[1
]}

DASHWOOD, MR ^{[1
]}

GILBEY, MP ^{[1
]}

机构：

[1] ROYAL FREE HOSP,SCH MED,DEPT PHYSIOL,ROWLAND HILL ST,LONDON NW3 2PF,ENGLAND

来源：

BRAIN RESEARCH | 1990年 / 530卷 / 02期

关键词：

Adrenoceptor; Methoxamine; Prazosin; Sympathetic preganglionic neuron; α[!sub]1[!/sub;

D O I：

10.1016/0006-8993(90)91303-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The autoradiographic localization of [3H]prazosin (α1-adrenoceptor ligand) binding sites was determined in cat spinal cord sections. High levels of [3H]prazosin binding were found in the intermediolateral cell column (IML) at thoracic and lumbar levels. The iontophoresis of the α1-adrenoceptor agonist methoxamine onto sympathetic preganglionic neurones (SPNs) in anaesthetized cats and rats caused excitation of 8 cat SPNs and 13 rat SPNs. These results suggest an excitatory role for some of the catecholaminergic of the IML. © 1990.

引用

页码：321 / 324

页数：4

共 18 条

[1]

ARIENS EJ, 1964, MOL PHARM, P119

[2] COMPARISON OF THE EFFECTS OF METHOXAMINE WITH THOSE OF NORADRENALINE AND PHENYLEPHRINE ON SINGLE CEREBRAL CORTICAL-NEURONS [J].

BRADSHAW, CM ;

PUN, RYK ;

SLATER, NT ;

SZABADI, E .

BRITISH JOURNAL OF PHARMACOLOGY, 1981, 73 (01) :47-54

[3] SUBTYPES OF ALPHA-2-ADRENOCEPTORS - PHARMACOLOGICAL AND MOLECULAR BIOLOGICAL EVIDENCE CONVERGE [J].

BYLUND, DB .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1988, 9 (10) :356-361

[4]

COOTE JH, 1989, J PHYSIOL-LONDON, V416, pP17

[5] THE LOCALIZATION OF ADRENOCEPTORS AND OPIATE RECEPTORS IN REGIONS OF THE CAT CENTRAL NERVOUS-SYSTEM INVOLVED IN CARDIOVASCULAR CONTROL [J].

DASHWOOD, MR ;

GILBEY, MP ;

SPYER, KM .

NEUROSCIENCE, 1985, 15 (02) :537-+

[6]

DASHWOOD MR, 1990, J PHYSL, V423, P768

[7] SOME CHARACTERISTICS OF SYMPATHETIC PREGANGLIONIC NEURONS IN THE RAT [J].

GILBEY, MP ;

PETERSON, DF ;

COOTE, JH .

BRAIN RESEARCH, 1982, 241 (01) :43-48

[8]

GUYENET PG, 1981, J NEUROSCI, V1, P908

[9] PHENYLETHANOLAMINE N-METHYLTRANSFERASE-CONTAINING TERMINALS SYNAPSE DIRECTLY ON SYMPATHETIC PREGANGLIONIC NEURONS IN THE RAT [J].

MILNER, TA ;

MORRISON, SF ;

ABATE, C ;

REIS, DJ .

BRAIN RESEARCH, 1988, 448 (02) :205-222

[10] EXCITATORY AND INHIBITORY EFFECTS OF EPINEPHRINE ON NEONATAL RAT SYMPATHETIC PREGANGLIONIC NEURONS INVITRO [J].

MIYAZAKI, T ;

COOTE, JH ;

DUN, NJ .

BRAIN RESEARCH, 1989, 497 (01) :108-116

← 1 2 →