[H-3] PRAZOSIN BINDING IN THE INTERMEDIOLATERAL CELL COLUMN AND THE EFFECTS OF IONTOPHORESED METHOXAMINE ON SYMPATHETIC PREGANGLIONIC NEURONAL-ACTIVITY IN THE ANESTHETIZED CAT AND RAT

被引：21

作者：

MARKS, SA ^{[1
]}

STEIN, RD ^{[1
]}

DASHWOOD, MR ^{[1
]}

GILBEY, MP ^{[1
]}

机构：

[1] ROYAL FREE HOSP,SCH MED,DEPT PHYSIOL,ROWLAND HILL ST,LONDON NW3 2PF,ENGLAND

来源：

BRAIN RESEARCH | 1990年 / 530卷 / 02期

关键词：

Adrenoceptor; Methoxamine; Prazosin; Sympathetic preganglionic neuron; α[!sub]1[!/sub;

D O I：

10.1016/0006-8993(90)91303-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The autoradiographic localization of [3H]prazosin (α1-adrenoceptor ligand) binding sites was determined in cat spinal cord sections. High levels of [3H]prazosin binding were found in the intermediolateral cell column (IML) at thoracic and lumbar levels. The iontophoresis of the α1-adrenoceptor agonist methoxamine onto sympathetic preganglionic neurones (SPNs) in anaesthetized cats and rats caused excitation of 8 cat SPNs and 13 rat SPNs. These results suggest an excitatory role for some of the catecholaminergic of the IML. © 1990.

引用

页码：321 / 324

页数：4

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