STRESS-TRIGGERED ABORTION - INHIBITION OF PROTECTIVE SUPPRESSION AND PROMOTION OF TUMOR NECROSIS FACTOR-ALPHA(TNF-ALPHA) RELEASE AS A MECHANISM TRIGGERING RESORPTIONS IN MICE

被引:86
作者
ARCK, PC
MERALI, FS
MANUEL, J
CHAOUAT, G
CLARK, DA
机构
[1] MCMASTER UNIV,DEPT MED,MOLEC VIROL IMMUNOL PROGRAM,HAMILTON,ON L8N 3Z5,CANADA
[2] MCMASTER UNIV,DEPT OBSTET & GYNAECOL,MOLEC VIROL IMMUNOL PROGRAM,HAMILTON,ON,CANADA
[3] HOSP ANTOINE BECLERE,DEPT OBSTET & GYNAECOL,CELLULAR & MOLEC BIOL MATERNOFETAL RELATIONSHIP U,CLAMART,FRANCE
来源
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 1995年 / 33卷 / 01期
关键词
IMMUNOLOGICAL ABORTION; STRESS; TNF-A; SUPPRESSIVE ACTIVITY; MICE;
D O I
10.1111/j.1600-0897.1995.tb01141.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
PROBLEM: Stress adversely affects pregnancy outcome and has been implicated as an abortogen in both animals and humans. However, the mechanisms whereby stress aborts are largely unknown. Alloimmunization can prevent stress-triggered abortion, and immunization is known to increase transforming growth factor-beta 2 (TGF-beta 2)-related suppressive activity. METHOD: To investigate these mechanisms, DBA/2J males were mated to CBA/J or C3H/ HeJ females, and the pregnant females were exposed to ultrasonic sound stress for a period of 24 h between day 4.5 to 8.5 of pregnancy. RESULTS: Ultrasonic stress significantly elevated the resorption rate with a peak effect on day 5.5 in the CBA/J females and on day 4.5 in the LPS-resistant C3H/HeJ females. The tumor necrosis factor-alpha (TNF-alpha) release from the decidua was also elevated and the TGF-beta 2-mediated suppressive activity was significantly decreased. The resorption rate only increased when the TNF-alpha/TGF-beta 2 ratio was increased compared to the control. CONCLUSION: These data suggest that stress may inhibit protective suppressor mechanisms and promote secretion of abortogenic cytokines such as TNF-alpha. Possible mechanisms are discussed.
引用
收藏
页码:74 / 80
页数:7
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