EARLY VENTRAL EXPRESSION OF THE DROSOPHILA NEUROGENIC LOCUS MASTERMIND

被引：11

作者：

BETTLER, D ^{[1
]}

SCHMID, A ^{[1
]}

YEDVOBNICK, B ^{[1
]}

机构：

[1] EMORY UNIV,DEPT BIOL,1510 CLIFTON RD,ATLANTA,GA 30322

来源：

DEVELOPMENTAL BIOLOGY | 1991年 / 144卷 / 02期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/0012-1606(91)90436-7

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The neurogenic locus mastermind (mam) of Drosophila is required for the segregation of epidermal from neural cell lineages. Previous studies have shown that during neurogenesis mam appears to be expressed throughout the ectoderm, mesoderm, and neuroblast layer of the germ band. Here it is demonstrated that during early embryogenesis mam is expressed ubiquitously; however, the predominant domains of accumulation of mam RNA and protein during gastrulation are along the ventral longitudinal surface, including cells of the mesoderm, endoderm, mesectoderm, and neuroectoderm. The regions of elevated mam accumulation coincide with the realm of action of dorsoventral patterning genes. © 1991.

引用

收藏

页码：436 / 439

页数：4

相关论文

共 21 条

[11]

KOPCZYNSKI CC, 1989, DEVELOPMENT, V107, P623

[12] DELTA, A DROSOPHILA NEUROGENIC GENE, IS TRANSCRIPTIONALLY COMPLEX AND ENCODES A PROTEIN RELATED TO BLOOD-COAGULATION FACTORS AND EPIDERMAL GROWTH-FACTOR OF VERTEBRATES [J].

KOPCZYNSKI, CC ;

ALTON, AK ;

FECHTEL, K ;

KOOH, PJ ;

MUSKAVITCH, MAT .

GENES & DEVELOPMENT, 1988, 2 (12B) :1723-1735

[13] MOLECULAR-GENETICS OF PECANEX, A MATERNAL-EFFECT NEUROGENIC LOCUS OF DROSOPHILA-MELANOGASTER THAT POTENTIALLY ENCODES A LARGE TRANSMEMBRANE PROTEIN [J].

LABONNE, SG ;

SUNITHA, I ;

MAHOWALD, AP .

DEVELOPMENTAL BIOLOGY, 1989, 136 (01) :1-16

[14] ON THE PHENOTYPE AND DEVELOPMENT OF MUTANTS OF EARLY NEUROGENESIS IN DROSOPHILA-MELANOGASTER [J].

LEHMANN, R ;

JIMENEZ, F ;

DIETRICH, U ;

CAMPOSORTEGA, JA .

WILHELM ROUXS ARCHIVES OF DEVELOPMENTAL BIOLOGY, 1983, 192 (02) :62-74

[15] SIMILARITY OF THE PRODUCT OF THE DROSOPHILA NEUROGENIC GENE BIG BRAIN TO TRANSMEMBRANE CHANNEL PROTEINS [J].

RAO, Y ;

JAN, LY ;

JAN, YN .

NATURE, 1990, 345 (6271) :163-167

[16] A GRADIENT OF NUCLEAR-LOCALIZATION OF THE DORSAL PROTEIN DETERMINES DORSOVENTRAL PATTERN IN THE DROSOPHILA EMBRYO [J].

ROTH, S ;

STEIN, D ;

NUSSLEINVOLHARD, C .

CELL, 1989, 59 (06) :1189-1202

[17] THE GRADED DISTRIBUTION OF THE DORSAL MORPHOGEN IS INITIATED BY SELECTIVE NUCLEAR TRANSPORT IN DROSOPHILA [J].

RUSHLOW, CA ;

HAN, KY ;

MANLEY, JL ;

LEVINE, M .

CELL, 1989, 59 (06) :1165-1177

[18] THE DROSOPHILA NEUROGENIC LOCUS MASTERMIND ENCODES A NUCLEAR-PROTEIN UNUSUALLY RICH IN AMINO-ACID HOMOPOLYMERS [J].

SMOLLER, D ;

FRIEDEL, C ;

SCHMID, A ;

BETTLER, D ;

LAM, L ;

YEDVOBNICK, B .

GENES & DEVELOPMENT, 1990, 4 (10) :1688-1700

[19] RELOCALIZATION OF THE DORSAL PROTEIN FROM THE CYTOPLASM TO THE NUCLEUS CORRELATES WITH ITS FUNCTION [J].

STEWARD, R .

CELL, 1989, 59 (06) :1179-1188

[20] MOLECULAR-GENETICS OF THE SINGLE-MINDED LOCUS - A GENE INVOLVED IN THE DEVELOPMENT OF THE DROSOPHILA NERVOUS-SYSTEM [J].

THOMAS, JB ;

CREWS, ST ;

GOODMAN, CS .

CELL, 1988, 52 (01) :133-141