PTF1 ENCODES AN ESSENTIAL PROTEIN IN SACCHAROMYCES-CEREVISIAE, WHICH SHOWS STRONG HOMOLOGY WITH A NEW PUTATIVE FAMILY OF PPIASES

被引：90

作者：

HANI, J ^{[1
]}

STUMPF, G ^{[1
]}

DOMDEY, H ^{[1
]}

机构：

[1] UNIV MUNICH, GENZENTRUM, D-81375 MUNICH, GERMANY

来源：

FEBS LETTERS | 1995年 / 365卷 / 2-3期

关键词：

PEPTIDYL-PROLYL CIS TRANS ISOMERASE; NUCLEOTIDE SEQUENCE; SEQUENCE HOMOLOGY; SACCHAROMYCES CEREVISIAE;

D O I：

10.1016/0014-5793(95)00471-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Complementation of a temperature sensitive mutant of the yeast Saccharomyces cerevisiae resulted in the isolation of PTF1 (processing/termination factor 1), an essential gene encoding a putative 3'-end processing or transcription termination factor of pre-mRNAs. Ptf1p shows significant homology to a newly discovered family of PPIases. This family is characterized by its insensitivity to immunosuppressive drugs and the lack of homology with cyclophilins and FK-506 binding proteins [Rahfeld et al, (1994) FEES Lett, 352, 180-184]. Should Ptf1p display PPIase activity, it would be the first characterized, eukaryotic member of this putative family, which is essential for growth.

引用

页码：198 / 202

页数：5

共 27 条

[1] THE CYCLOPHILIN HOMOLOG NINAA FUNCTIONS AS A CHAPERONE, FORMING A STABLE COMPLEX IN-VIVO WITH ITS PROTEIN TARGET RHODOPSIN
BAKER, EK
COLLEY, NJ
ZUKER, CS
[J]. EMBO JOURNAL, 1994, 13 (20) : 4886 - 4895
[2] BULLOCK WO, 1987, BIOTECHNIQUES, V5, P376
[3] SUPERCOIL SEQUENCING - A FAST AND SIMPLE METHOD FOR SEQUENCING PLASMID DNA
CHEN, EY
SEEBURG, PH
[J]. DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY, 1985, 4 (02): : 165 - 170
[4] LARIAT STRUCTURES ARE INVIVO INTERMEDIATES IN YEAST PRE-MESSENGER RNA SPLICING
DOMDEY, H
APOSTOL, B
LIN, RJ
NEWMAN, A
BRODY, E
ABELSON, J
[J]. CELL, 1984, 39 (03) : 611 - 621
[5] Fischer G, 1994, ANGEW CHEM, V106, P1479
[6] RAPID PRODUCTION OF FULL-LENGTH CDNAS FROM RARE TRANSCRIPTS - AMPLIFICATION USING A SINGLE GENE-SPECIFIC OLIGONUCLEOTIDE PRIMER
FROHMAN, MA
DUSH, MK
MARTIN, GR
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (23) : 8998 - 9002
[7] GOODALL GJ, 1990, METHOD ENZYMOL, V181, P148
[8] SEQUENCE AND MUTATIONAL ANALYSIS OF ESS1, A GENE ESSENTIAL FOR GROWTH IN SACCHAROMYCES-CEREVISIAE
HANES, SD
SHANK, PR
BOSTIAN, KA
[J]. YEAST, 1989, 5 (01) : 55 - 72
[9] IDENTIFICATION OF PRE-MESSENGER-RNA POLYADENYLATION SITES IN SACCHAROMYCES-CEREVISIAE
HEIDMANN, S
OBERMAIER, B
VOGEL, K
DOMDEY, H
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (09) : 4215 - 4229
[10] UNIDIRECTIONAL DIGESTION WITH EXONUCLEASE-III CREATES TARGETED BREAKPOINTS FOR DNA SEQUENCING
HENIKOFF, S
[J]. GENE, 1984, 28 (03) : 351 - 359

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