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EFFECT OF THYROTROPIN-RELEASING-HORMONE ON THE TIME COURSE OF NEUROLOGIC RECOVERY AFTER SPINAL-CORD INJURY IN THE RAT
被引:15
作者
:
HASHIMOTO, T
论文数:
0
引用数:
0
h-index:
0
机构:
Research and Development Division, Takeda Chemical Industries Ltd., Osaka, 2-17-85, Juso-Honmachi, Yodogawa-ku
HASHIMOTO, T
FUKUDA, N
论文数:
0
引用数:
0
h-index:
0
机构:
Research and Development Division, Takeda Chemical Industries Ltd., Osaka, 2-17-85, Juso-Honmachi, Yodogawa-ku
FUKUDA, N
机构
:
[1]
Research and Development Division, Takeda Chemical Industries Ltd., Osaka, 2-17-85, Juso-Honmachi, Yodogawa-ku
来源
:
JAPANESE JOURNAL OF PHARMACOLOGY
|
1990年
/ 53卷
/ 04期
关键词
:
D O I
:
10.1254/jjp.53.479
中图分类号
:
R9 [药学];
学科分类号
:
1007 ;
摘要
:
Spinal cord injuries in rats were experimentally produced by compressing the cord at the eleventh thoracic vertebral level for 60 minutes with stainless steel screws (2 mm in diameter and 2.8 mm in length). The main neurologic signs produced by cord compression were motor as well as sensory deficits and urinary incontinence. Rats with a neurologic score, based on both motor and sensory deficits, of 1 (complete paraplegia but responsive to tail pinching) 24 hours after injury were used to study the relative effect of subcutaneous treatment with TRH once or twice daily for 7 consecutive days on the time course of recovery after spinal cord injury and the dose-dependency of this effect. Once daily (5.15, or 45 mg/kg/day) or twice daily (2.5, 7.5, or 22.5 mg/kgx2/day) treatment with TRH starting 24 hours after injury improved the neurological signs and reduced the incidence of urinary incontinence, dose-dependently. The minimum effective doses for once and twice daily treatments were 45 mg/kg/day and 7.5 mg/kg x 2/day. These results indicate that the neurologic recovery-accelerating effect of TRH administered 24 hours after cord injury for 7 days is dose-dependent and that a twice daily dosage schedule tends to produce better improvement in the neurologic state than a once daily schedule dose. © 1990, The Japanese Pharmacological Society. All rights reserved.
引用
收藏
页码:479 / 486
页数:8
相关论文
共 28 条
[21]
MANAKA S, 1977, BRAIN NERV, V29, P1075
[22]
CLINICAL EFFECTS OF THYROTROPIN-RELEASING-HORMONE FOR SEVERE EPILEPSY IN CHILDHOOD - A COMPARATIVE-STUDY WITH ACTH THERAPY
MATSUMOTO, A
论文数:
0
引用数:
0
h-index:
0
机构:
NAGOYA UNIV,SCH MED,DEPT PEDIAT,NAGOYA,AICHI 466,JAPAN
NAGOYA UNIV,SCH MED,DEPT PEDIAT,NAGOYA,AICHI 466,JAPAN
MATSUMOTO, A
KUMAGAI, T
论文数:
0
引用数:
0
h-index:
0
机构:
NAGOYA UNIV,SCH MED,DEPT PEDIAT,NAGOYA,AICHI 466,JAPAN
NAGOYA UNIV,SCH MED,DEPT PEDIAT,NAGOYA,AICHI 466,JAPAN
KUMAGAI, T
TAKEUCHI, T
论文数:
0
引用数:
0
h-index:
0
机构:
NAGOYA UNIV,SCH MED,DEPT PEDIAT,NAGOYA,AICHI 466,JAPAN
NAGOYA UNIV,SCH MED,DEPT PEDIAT,NAGOYA,AICHI 466,JAPAN
TAKEUCHI, T
MIYAZAKI, S
论文数:
0
引用数:
0
h-index:
0
机构:
NAGOYA UNIV,SCH MED,DEPT PEDIAT,NAGOYA,AICHI 466,JAPAN
NAGOYA UNIV,SCH MED,DEPT PEDIAT,NAGOYA,AICHI 466,JAPAN
MIYAZAKI, S
WATANABE, K
论文数:
0
引用数:
0
h-index:
0
机构:
NAGOYA UNIV,SCH MED,DEPT PEDIAT,NAGOYA,AICHI 466,JAPAN
NAGOYA UNIV,SCH MED,DEPT PEDIAT,NAGOYA,AICHI 466,JAPAN
WATANABE, K
[J].
EPILEPSIA,
1987,
28
(01)
: 49
-
55
[23]
RESTITUTION OF FUNCTION AND COLLATERAL SPROUTING IN CAT SPINAL-CORD - PARTIALLY HEMISECTED ANIMAL
MURRAY, M
论文数:
0
引用数:
0
h-index:
0
机构:
MED COLL PENN, DEPT ANAT, PHILADELPHIA, PA 19129 USA
MED COLL PENN, DEPT ANAT, PHILADELPHIA, PA 19129 USA
MURRAY, M
GOLDBERGER, ME
论文数:
0
引用数:
0
h-index:
0
机构:
MED COLL PENN, DEPT ANAT, PHILADELPHIA, PA 19129 USA
MED COLL PENN, DEPT ANAT, PHILADELPHIA, PA 19129 USA
GOLDBERGER, ME
[J].
JOURNAL OF COMPARATIVE NEUROLOGY,
1974,
158
(01)
: 19
-
36
[24]
CORRELATIVE ANALYSES OF LESION DEVELOPMENT AND FUNCTIONAL STATUS AFTER GRADED SPINAL-CORD CONTUSIVE INJURIES IN THE RAT
NOBLE, LJ
论文数:
0
引用数:
0
h-index:
0
机构:
GEORGETOWN UNIV,DEPT ANAT & CELL BIOL,3900 RESERVOIR RD,WASHINGTON,DC 20007
GEORGETOWN UNIV,DEPT ANAT & CELL BIOL,3900 RESERVOIR RD,WASHINGTON,DC 20007
NOBLE, LJ
WRATHALL, JR
论文数:
0
引用数:
0
h-index:
0
机构:
GEORGETOWN UNIV,DEPT ANAT & CELL BIOL,3900 RESERVOIR RD,WASHINGTON,DC 20007
GEORGETOWN UNIV,DEPT ANAT & CELL BIOL,3900 RESERVOIR RD,WASHINGTON,DC 20007
WRATHALL, JR
[J].
EXPERIMENTAL NEUROLOGY,
1989,
103
(01)
: 34
-
40
[25]
ANTIEPILEPTIC EFFECTS OF THYROTROPIN-RELEASING-HORMONE AND ITS NEW DERIVATIVE, DN-1417, EXAMINED IN FELINE AMYGDALOID KINDLING PREPARATION
SATO, M
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BRITISH COLUMBIA,DIV NEUROSCI,VANCOUVER V6T 2A1,BC,CANADA
SATO, M
MORIMOTO, K
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BRITISH COLUMBIA,DIV NEUROSCI,VANCOUVER V6T 2A1,BC,CANADA
MORIMOTO, K
WADA, JA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BRITISH COLUMBIA,DIV NEUROSCI,VANCOUVER V6T 2A1,BC,CANADA
WADA, JA
[J].
EPILEPSIA,
1984,
25
(05)
: 537
-
544
[26]
THYROTROPIN-RELEASING-HORMONE ENHANCES CHOLINE-ACETYLTRANSFERASE AND CREATINE-KINASE IN CULTURED SPINAL VENTRAL HORN NEURONS
SCHMIDTACHERT, KM
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV SO CALIF, CTR NEUROMUSCULAR, LOS ANGELES, CA 90017 USA
SCHMIDTACHERT, KM
ASKANAS, V
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV SO CALIF, CTR NEUROMUSCULAR, LOS ANGELES, CA 90017 USA
ASKANAS, V
ENGEL, WK
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV SO CALIF, CTR NEUROMUSCULAR, LOS ANGELES, CA 90017 USA
ENGEL, WK
[J].
JOURNAL OF NEUROCHEMISTRY,
1984,
43
(02)
: 586
-
589
[27]
SOBUE I, 1986, TRH SPINOCEREBELLAR
[28]
EFFECTS OF THYROTROPIN-RELEASING-HORMONE ON BEHAVIORAL AND HORMONAL CHANGES INDUCED BY BETA-ENDORPHIN
TACHE, Y
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MONTREAL,HOP ST JUSTINE,CTR RECH PEDIAT,MONTREAL,QUEBEC,CANADA
TACHE, Y
LIS, M
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MONTREAL,HOP ST JUSTINE,CTR RECH PEDIAT,MONTREAL,QUEBEC,CANADA
LIS, M
COLLU, R
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MONTREAL,HOP ST JUSTINE,CTR RECH PEDIAT,MONTREAL,QUEBEC,CANADA
COLLU, R
[J].
LIFE SCIENCES,
1977,
21
(06)
: 841
-
846
←
1
2
3
→
共 28 条
[21]
MANAKA S, 1977, BRAIN NERV, V29, P1075
[22]
CLINICAL EFFECTS OF THYROTROPIN-RELEASING-HORMONE FOR SEVERE EPILEPSY IN CHILDHOOD - A COMPARATIVE-STUDY WITH ACTH THERAPY
MATSUMOTO, A
论文数:
0
引用数:
0
h-index:
0
机构:
NAGOYA UNIV,SCH MED,DEPT PEDIAT,NAGOYA,AICHI 466,JAPAN
NAGOYA UNIV,SCH MED,DEPT PEDIAT,NAGOYA,AICHI 466,JAPAN
MATSUMOTO, A
KUMAGAI, T
论文数:
0
引用数:
0
h-index:
0
机构:
NAGOYA UNIV,SCH MED,DEPT PEDIAT,NAGOYA,AICHI 466,JAPAN
NAGOYA UNIV,SCH MED,DEPT PEDIAT,NAGOYA,AICHI 466,JAPAN
KUMAGAI, T
TAKEUCHI, T
论文数:
0
引用数:
0
h-index:
0
机构:
NAGOYA UNIV,SCH MED,DEPT PEDIAT,NAGOYA,AICHI 466,JAPAN
NAGOYA UNIV,SCH MED,DEPT PEDIAT,NAGOYA,AICHI 466,JAPAN
TAKEUCHI, T
MIYAZAKI, S
论文数:
0
引用数:
0
h-index:
0
机构:
NAGOYA UNIV,SCH MED,DEPT PEDIAT,NAGOYA,AICHI 466,JAPAN
NAGOYA UNIV,SCH MED,DEPT PEDIAT,NAGOYA,AICHI 466,JAPAN
MIYAZAKI, S
WATANABE, K
论文数:
0
引用数:
0
h-index:
0
机构:
NAGOYA UNIV,SCH MED,DEPT PEDIAT,NAGOYA,AICHI 466,JAPAN
NAGOYA UNIV,SCH MED,DEPT PEDIAT,NAGOYA,AICHI 466,JAPAN
WATANABE, K
[J].
EPILEPSIA,
1987,
28
(01)
: 49
-
55
[23]
RESTITUTION OF FUNCTION AND COLLATERAL SPROUTING IN CAT SPINAL-CORD - PARTIALLY HEMISECTED ANIMAL
MURRAY, M
论文数:
0
引用数:
0
h-index:
0
机构:
MED COLL PENN, DEPT ANAT, PHILADELPHIA, PA 19129 USA
MED COLL PENN, DEPT ANAT, PHILADELPHIA, PA 19129 USA
MURRAY, M
GOLDBERGER, ME
论文数:
0
引用数:
0
h-index:
0
机构:
MED COLL PENN, DEPT ANAT, PHILADELPHIA, PA 19129 USA
MED COLL PENN, DEPT ANAT, PHILADELPHIA, PA 19129 USA
GOLDBERGER, ME
[J].
JOURNAL OF COMPARATIVE NEUROLOGY,
1974,
158
(01)
: 19
-
36
[24]
CORRELATIVE ANALYSES OF LESION DEVELOPMENT AND FUNCTIONAL STATUS AFTER GRADED SPINAL-CORD CONTUSIVE INJURIES IN THE RAT
NOBLE, LJ
论文数:
0
引用数:
0
h-index:
0
机构:
GEORGETOWN UNIV,DEPT ANAT & CELL BIOL,3900 RESERVOIR RD,WASHINGTON,DC 20007
GEORGETOWN UNIV,DEPT ANAT & CELL BIOL,3900 RESERVOIR RD,WASHINGTON,DC 20007
NOBLE, LJ
WRATHALL, JR
论文数:
0
引用数:
0
h-index:
0
机构:
GEORGETOWN UNIV,DEPT ANAT & CELL BIOL,3900 RESERVOIR RD,WASHINGTON,DC 20007
GEORGETOWN UNIV,DEPT ANAT & CELL BIOL,3900 RESERVOIR RD,WASHINGTON,DC 20007
WRATHALL, JR
[J].
EXPERIMENTAL NEUROLOGY,
1989,
103
(01)
: 34
-
40
[25]
ANTIEPILEPTIC EFFECTS OF THYROTROPIN-RELEASING-HORMONE AND ITS NEW DERIVATIVE, DN-1417, EXAMINED IN FELINE AMYGDALOID KINDLING PREPARATION
SATO, M
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BRITISH COLUMBIA,DIV NEUROSCI,VANCOUVER V6T 2A1,BC,CANADA
SATO, M
MORIMOTO, K
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BRITISH COLUMBIA,DIV NEUROSCI,VANCOUVER V6T 2A1,BC,CANADA
MORIMOTO, K
WADA, JA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BRITISH COLUMBIA,DIV NEUROSCI,VANCOUVER V6T 2A1,BC,CANADA
WADA, JA
[J].
EPILEPSIA,
1984,
25
(05)
: 537
-
544
[26]
THYROTROPIN-RELEASING-HORMONE ENHANCES CHOLINE-ACETYLTRANSFERASE AND CREATINE-KINASE IN CULTURED SPINAL VENTRAL HORN NEURONS
SCHMIDTACHERT, KM
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV SO CALIF, CTR NEUROMUSCULAR, LOS ANGELES, CA 90017 USA
SCHMIDTACHERT, KM
ASKANAS, V
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV SO CALIF, CTR NEUROMUSCULAR, LOS ANGELES, CA 90017 USA
ASKANAS, V
ENGEL, WK
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV SO CALIF, CTR NEUROMUSCULAR, LOS ANGELES, CA 90017 USA
ENGEL, WK
[J].
JOURNAL OF NEUROCHEMISTRY,
1984,
43
(02)
: 586
-
589
[27]
SOBUE I, 1986, TRH SPINOCEREBELLAR
[28]
EFFECTS OF THYROTROPIN-RELEASING-HORMONE ON BEHAVIORAL AND HORMONAL CHANGES INDUCED BY BETA-ENDORPHIN
TACHE, Y
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MONTREAL,HOP ST JUSTINE,CTR RECH PEDIAT,MONTREAL,QUEBEC,CANADA
TACHE, Y
LIS, M
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MONTREAL,HOP ST JUSTINE,CTR RECH PEDIAT,MONTREAL,QUEBEC,CANADA
LIS, M
COLLU, R
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MONTREAL,HOP ST JUSTINE,CTR RECH PEDIAT,MONTREAL,QUEBEC,CANADA
COLLU, R
[J].
LIFE SCIENCES,
1977,
21
(06)
: 841
-
846
←
1
2
3
→