COMPARISON OF MOTOR RESPONSE TO APOMORPHINE AND LEVODOPA IN PARKINSONS-DISEASE

被引：91

作者：

KEMPSTER, PA ^{[1
]}

FRANKEL, JP ^{[1
]}

STERN, GM ^{[1
]}

LEES, AJ ^{[1
]}

机构：

[1] UNIV COLL HOSP LONDON,SCH MED,WC1 LONDON,ENGLAND

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1990年 / 53卷 / 11期

关键词：

D O I：

10.1136/jnnp.53.11.1004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The magnitude and pattern of motor responses to single doses of subcutaneous apomorphine and oral levodopa were compared in 14 patients with Parkinson's disease. Although apomorphine produced much shorter motor responses than levodopa, the quality of response to the two drugs was virtually indistinguishable. These clinical observations support the notion that integrity of striatal post-synaptic dopamine receptors is a key determinant of responsiveness to dopaminergic treatment in Parkinson's disease.

引用

页码：1004 / 1007

页数：4