Intrinsic resistance to chemotherapy in breast cancer

被引：16

作者：

Moulder, Stacy ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Breast Med Oncol, Unit 1354, POB 301438, Houston, TX 77030 USA

来源：

WOMENS HEALTH | 2010年 / 6卷 / 06期

关键词：

adjuvant therapy; biologic therapy; breast cancer intrinsic; resistance; metastatic disease; targeted therapy;

D O I：

10.2217/WHE.10.60

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Systemic therapy improves disease-free survival in patients with breast cancer, but does not cure patients with advanced or metastatic disease, and fails to benefit the majority of patients with localized breast cancer. Intrinsic resistance to chemotherapy is emerging as a significant cause of treatment failure and evolving research has identified several potential causes of resistance, such as drug efflux pumps, disregulation of apoptosis and cancer stem cells. Building upon preclinical models, drugs designed to reverse resistance to therapy are currently under investigation in clinical trials for the treatment of breast cancer.

引用

页码：821 / 830

页数：10

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