ACETYLCHOLINE-RECEPTOR CHANNEL IMAGED IN THE OPEN STATE

被引：887

作者：

UNWIN, N

机构：

[1] MRC Laboratory of Molecular Biology, Cambridge, CB2 2QH, Hills Road

来源：

NATURE | 1995年 / 373卷 / 6509期

关键词：

D O I：

10.1038/373037a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The structure of the open-channel form of the acetylcholine receptor has been determined from electron images of Torpedo ray postsynaptic membranes activated by brief (<5 ms) mixing with droplets containing acetylcholine. Comparison with the closed-channel form shows that acetylcholine Initiates small rotations of the subunits in the extracellular domain, which trigger a change in configuration of a-helices lining the membrane-spanning pore. The open pore tapers towards the intracellular membrane face, where it is shaped by a 'barrel' of a-helices having a pronounced right-handed twist.

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页码：37 / 43

页数：7

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