EFFECTS OF GALANIN ON SHORT-CIRCUIT CURRENT AND ELECTROLYTE TRANSPORT IN RABBIT ILEUM

被引：17

作者：

HOMAIDAN, FR

TANG, SH

DONOWITZ, M

SHARP, GWG

机构：

[1] SUNY STONY BROOK,SCH MED,MINEOLA,NY 11501

[2] CORNELL UNIV,COLL VET MED,DEPT PHARMACOL,ITHACA,NY 14853

[3] JOHNS HOPKINS UNIV,SCH MED,DEPT MED,BALTIMORE,MD 21205

[4] JOHNS HOPKINS UNIV,SCH MED,DEPT PHYSIOL,BALTIMORE,MD 21205

来源：

PEPTIDES | 1994年 / 15卷 / 08期

关键词：

GALANIN; NACL ABSORPTION; ELECTROLYTE TRANSPORT;

D O I：

10.1016/0196-9781(94)90120-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Galanin decreased short circuit current (I-sc) and increased active Na+ and Cl- absorption in rabbit ileum. In the absence of calcium, the galanin-induced decrease in I-sc was inhibited by approximately 60%. Tetrodotoxin significantly reduced the effect of galanin on I-sc and tetrodotoxin and EGTA totally blocked the effect, indicating that the nonneuronal mediator of the effect is Ca2+ dependent. Galanin binding to basolateral membranes prepared from ileal epithelial cells was specific and of high affinity. These results suggest the involvement of this peptide in the regulation of intestinal epithelial cell function.

引用

页码：1431 / 1436

页数：6

共 23 条

[1] GALANIN INHIBITS GLUCOSE-STIMULATED INSULIN RELEASE BY A MECHANISM INVOLVING HYPERPOLARIZATION AND LOWERING OF CYTOPLASMIC FREE CA-2+ CONCENTRATION [J].