TELOMERES, TELOMERASE AND SENESCENCE

被引：236

作者：

GREIDER, CW

机构：

[1] Cold Spring Harbor Laboratory, Cold Spring, New York, 11724, P.O. Box 100, , Harbor

来源：

BIOESSAYS | 1990年 / 12卷 / 08期

关键词：

D O I：

10.1002/bies.950120803

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eukaryotic chromosomes end with tandem repeats of simple sequences. These GC rich repeats allow telomere replication and stabilize chromosome ends. Telomere replication involves an equilibrium of sequence loss and addition at the ends of chromosomes. Repeats are added de novo by telomerase, an unusual DNA polymerase. Telomerase is an RNP in which an essential RNA component provides the template for the added telomere repeats. Telomere length maintenance plays an essential role in cell viability. Copyright © 1990 Cambridge University Press

引用

页码：363 / 369

页数：7

共 58 条

[31]

LUNDBLAD V, 1990, CELL, V60, P529

[32] IDENTIFICATION OF HEALED TERMINAL DNA FRAGMENTS IN LINEAR MINICHROMOSOMES OF SCHIZOSACCHAROMYCES-POMBE [J].