PHOSPHATE DERIVATIVES OF D4T AS INHIBITORS OF HIV

被引：30

作者：

MCGUIGAN, C

SHEEKA, HM

MAHMOOD, N

HAY, A

机构：

[1] MRC,COLLABORAT CTR,LONDON NW7 1AD,ENGLAND

[2] NATL INST MED RES,LONDON NW7 1AA,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(00)80315-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Phosphate derivatives of the anti-HIV nucleoside analogue d4T were prepared as potential pro-drugs of the bio-active free nucleotide. The anti-viral activity of the derivatives varies greatly with the phosphate structure. but several are active below 1 muM. All of the compounds are less toxic than the parent nucleoside analogue; in one case this leads to enhanced antiviral selectivity.

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页码：1203 / 1206

页数：4

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