ROLE OF KUPFFER CELLS IN INTERLEUKIN-6 RELEASE FOLLOWING TRAUMA-HEMORRHAGE AND RESUSCITATION

被引:118
作者
ONEILL, PJ
AYALA, A
WANG, P
BA, ZF
MORRISON, MH
SCHULTZE, AE
REICH, SS
CHAUDRY, IH
机构
[1] MICHIGAN STATE UNIV,DEPT SURG,SHOCK & TRAUMA RES LABS,B-424 CLIN CTR,E LANSING,MI 48824
[2] MICHIGAN STATE UNIV,DEPT PHYSIOL,E LANSING,MI 48824
[3] MICHIGAN STATE UNIV,DEPT MICROBIOL,E LANSING,MI 48824
[4] MICHIGAN STATE UNIV,DEPT PHARMACOL & TOXICOL,E LANSING,MI 48824
来源
SHOCK | 1994年 / 1卷 / 01期
关键词
D O I
10.1097/00024382-199401000-00008
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Although Interleukin-6 (IL-6) plays an important role in the pathophysiology of trauma-hemorrhage and resuscitation, the cellular origin of this inflammatory cytokine remains unknown. This study was undertaken to determine whether Kupffer cells (KC) are a major source of IL-6 release following trauma-hemorrhage and resuscitation. KC numbers were significantly (p < .05) reduced in vivo with gadolinium chloride (GdCl3; 10 mg/kg IV). KC-reduced (KC(-)) and KC-normal (saline-treated; KC(+)) rats underwent laparotomy (i.e., trauma-induced), followed by either sham operation or hemorrhage. Hemorrhaged rats were bled to and maintained at a mean arterial pressure of 40 mmHg until 40% of the shed blood volume was returned as Ringer's lactate, and then resuscitated with Ringer's lactate (four times shed blood volume over 1 h). Results indicate that KC reduction per se had no effect on any measured parameter at any time. At 0.5 and 2.0 h postresuscitation, mean arterial pressure, heart rate, cardiac output, stroke volume, and hematocrit were reduced to a similar extent in both the KC(+) and KC(-) hemorrhage groups. KC reduction did, however, significantly reduce plasma IL-6 concentration (means +/- S.E.; U/ml) at both 0.5 h (KC(+) = 709 +/- 391 vs. KC(-) = 159 +/- 5) and at 2.0 h (KC(+) = 527 +/- 394 vs. KC(-) = 83 +/- 20) postresuscitation. In conclusion, this study demonstrates that KC are a major source of in vivo IL-6 release following trauma-hemorrhage and resuscitation.
引用
收藏
页码:43 / 47
页数:5
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