A PILOT-STUDY ON THE URINARY-EXCRETION OF PORPHYRINS IN HUMAN-POPULATIONS CHRONICALLY EXPOSED TO ARSENIC IN MEXICO

被引：32

作者：

GARCIAVARGAS, GG

GARCIARANGEL, A

AGUILARROMO, M

GARCIASALCEDO, J

DELRAZO, LM

OSTROSKYWEGMAN, P

DENAVA, CC

CEBRIAN, ME

机构：

[1] INST POLITECN NACL, CINVESTAV, DEPT FARMACOL & TOXICOL, POB 14740, MEXICO CITY 07000, MEXICO

[2] UNIV AUTONOMA COAHUILA, FAC MED, TORREON 27000, COAHUILA, MEXICO

[3] NATL AUTONOMOUS UNIV MEXICO, INST INVEST BIOMED, MEXICO CITY 04510, DF, MEXICO

来源：

HUMAN & EXPERIMENTAL TOXICOLOGY | 1991年 / 10卷 / 03期

关键词：

D O I：

10.1177/096032719101000307

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

1 The aim of this pilot study was to investigate if the porphyrinuria produced by arsenic in rodents was present in humans chronically exposed to arsenic via drinking water. 2 The concentrations of uroporphyrin, coproporphyrin and total arsenic in urine were compared between 21 individuals exposed to arsenic in their drinking water (0.390 mg 1(-1)) and 19 controls exposed to 0.012 mg 1(-1). 3 Arsenic-exposed individuals had significantly higher total arsenic concentrations in their urine than the control group. No increase in urinary porphyrin excretion was found in exposed individuals. However, an inversion of the coproporphyrin/uroporphyrin (COPRO/URO) ratio was observed in most exposed individuals. This inversion was caused both, by a decrease in coproporphyrin excretion and an increase in uroporphyrin excretion. 4 No demonstrable correlations between prophyrin excretion, the COPRO/URO ratio and total arsenic concentration in urine were found in exposed individuals.

引用

页码：189 / 193

页数：5

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