THE EFFECT OF MIXED BOVINE BRAIN GANGLIOSIDES ON HYPOXIC CONDUCTION BLOCK IN CONTROL AND STREPTOZOTOCIN-DIABETIC RATS

被引：2

作者：

CALCUTT, NA ^{[1
]}

CARRINGTON, AL ^{[1
]}

ETTLINGER, CB ^{[1
]}

TOMLINSON, DR ^{[1
]}

机构：

[1] UNIV LONDON,QUEEN MARY & WESTFIELD COLL,SCH BASIC MED SCI,DEPT PHARMACOL,LONDON E1 4NS,ENGLAND

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1992年 / 109卷 / 01期

基金：

英国惠康基金;

关键词：

DIABETES-MELLITUS; DIABETIC NEUROPATHY; HYPOXIA; NERVE CONDUCTION BLOCK; GANGLIOSIDES;

D O I：

10.1016/0022-510X(92)90100-Y

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This study describes the electrophysiological responses of endoneurial preparations derived from rat sciatic nerve to acute hypoxia in vitro. Preparations from control rats exhibited a 40% decline in compound action potential (CAP) amplitude after 40 min exposure to medium gassed with 8% O2. In preparations from 4 week streptozotocin-diabetic rats CAP declined by only 29%, indicating a resistance to hypoxic conduction blockade. Treating diabetic rats with mixed bovine brain gangliosides (10 mg/kg/day i.p.) exaggerated this resistance to hypoxic conduction blockade as CAP amplitude fell to only 18% of initial values. In a separate experiment, treating non-diabetic rats with gangliosides (10 mg/kg/day i.p.) or adding gangliosides (400-mu-g/ml) directly to the medium in which control nerves were maintained during in vitro recording also significantly attenuated the decline in CAP amplitude after 40 min hypoxia, thus effectively inducing a resistance to hypoxic conduction blockade similar to that observed in nerves from diabetic rats. These studies demonstrate that the systemic or acute local administration of gangliosides induces a resistance to hypoxic conduction block in normal nerve and exaggerates the resistance to hypoxic conduction block od diabetic rats.

引用

页码：96 / 101

页数：6