CHARACTERIZATION OF SULPHOALKYL ETHER DERIVATIVES OF BETA-CYCLODEXTRIN BY CAPILLARY ELECTROPHORESIS WITH INDIRECT UV DETECTION

被引：110

作者：

TAIT, RJ

SKANCHY, DJ

THOMPSON, DP

CHETWYN, NC

DUNSHEE, DA

RAJEWSKI, RA

STELLA, VJ

STOBAUGH, JF

机构：

[1] UNIV KANSAS,CTR BIOANALYT RES,2095 CONSTANT AVE,LAWRENCE,KS 66045

[2] UNIV KANSAS,CTR DRUG DELIVERY RES,LAWRENCE,KS 66045

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1992年 / 10卷 / 09期

关键词：

CAPILLARY ELECTROPHORESIS; SULPHOALKYL ETHER BETA-CYCLODEXTRIN(S); BETA-CYCLODEXTRIN; INDIRECT UV DETECTION;

D O I：

10.1016/0731-7085(92)80088-5

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A capillary electrophoresis method which characterizes the degrees of substitution of heterogeneous sulphoalkyl ether beta-cyclodextrin derivatives is described. The separation is based on the different electrophoretic mobilities observed from changes in the overall charge of the molecule as a result of substitution. Individual peaks of the electropherogram then provide a measure of each degree of substitution of the parent beta-cyclodextrin. Detection of these beta-cyclodextrin derivatives is performed by indirect UV detection.

引用

页码：615 / 622

页数：8

共 31 条

[1]

BAEYENS W R G, 1988, Anales de la Real Academia de Farmacia, V54, P698

[2] CYCLODEXTRIN CHEMISTRY - SELECTIVE MODIFICATION OF ALL PRIMARY HYDROXYL-GROUPS OF ALPHA-CYCLODEXTRINS AND BETA-CYCLODEXTRINS [J].