INDUCTION OF SISTER-CHROMATID EXCHANGES BY ALUI, DNASE-I, BENZON NUCLEASE AND BLEOMYCIN IN CHINESE-HAMSTER OVARY (CHO) CELLS

被引：16

作者：

OBE, G

SCHUNCK, C

JOHANNES, C

机构：

[1] University GH Essen, Department of Genetics, D-45117 Essen

来源：

MUTATION RESEARCH | 1994年 / 307卷 / 01期

关键词：

SISTER-CHROMATID EXCHANGE; DNA BREAK REPAIR;

D O I：

10.1016/0027-5107(94)90305-0

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Various endonucleases (AluI, DNase I, benzon nuclease) and bleomycin induce sister-chromatid exchanges (SCE) in Chinese hamster ovary (CHO) cells. The frequencies of SCE are elevated in cells with chromosome-type aberrations, only slightly elevated in cells with chromatid exchanges, and in the control range in cells without chromosomal aberrations. These data indicate that SCE are produced when DNA breaks induced in G1 are either not repaired or misrepaired.

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页码：315 / 321

页数：7

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