FISSION YEAST GENE STRUCTURE AND RECOGNITION

被引:66
作者
ZHANG, MQ
MARR, TG
机构
[1] Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724
关键词
D O I
10.1093/nar/22.9.1750
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A database of 210 Schizosaccharomyces pombe DNA sequences (524,794 bp) was extracted from GenBank (release number 81.0) and examined by a number of methods in order to characterize statistical features of these sequences that might serve as signals or constraints for messenger RNA splicing. The statistical information compiled includes splicing signal (donor, acceptor and branch site) profiles, translational initiation start profile, exon/intron length distributions, ORF distribution, CDS size distribution, codon usage table, and 6-tuple distribution. The information content of the various signals are also presented. A rule-based interactive computer program for finding introns called INTRON.PLOT has been developed and was used to successfully analyze 7 newly sequenced genes.
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页码:1750 / 1759
页数:10
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