HPLC RESOLUTION OF HYDROXYL CARBOXYLIC-ACID ENANTIOMERS USING 2-QUINOXALOYL CHLORIDE AS A NEW PRECOLUMN DERIVATIZING AGENT

被引:13
作者
BRIGHTWELL, M
PAWLOWSKA, M
ZUKOWSKI, J
机构
[1] SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex
来源
JOURNAL OF LIQUID CHROMATOGRAPHY | 1995年 / 18卷 / 14期
关键词
D O I
10.1080/10826079508009323
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Chiral alpha-hydroxy carboxylic acids were reacted using 2-quinoxaloyl chloride to form UV and fluorescent derivatives. Under mild conditions either in aqueous or non-aqueous conditions reaction proceeds quickly and without racemisation. The labelled compounds have been resolved into enantiomers on beta-cyclodextrin bonded stationary phase operated with polar organic eluents. The high sensitivity and selectivity of the method has been used for the determination of low levels of enantiomeric impurities in commercial ''pure'' samples.
引用
收藏
页码:2765 / 2781
页数:17
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