NATURAL-KILLER-CELL RECEPTORS

被引：141

作者：

YOKOYAMA, WM

机构：

[1] Howard Hughes Medical Institute, Department of Medicine, Mount Sinai Medical Center, New York, NY 10029-6574, One Gustave L Levy Place

来源：

CURRENT OPINION IN IMMUNOLOGY | 1995年 / 7卷 / 01期

关键词：

D O I：

10.1016/0952-7915(95)80036-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the past year, significant strides have been made in understanding natural killing, the process whereby natural killer cells lyse target cells. Recognition of susceptible targets' and activation now appear to be mediated by a natural killer cell receptor that binds carbohydrate determinants on target cells and initiates target lysis. Conversely, receptors have been identified that bind MHC class I molecules on targets that inhibit natural killer cell activation. These findings provide the basis for understanding the molecular processes in the initial steps of natural killing.

引用

页码：110 / 120

页数：11

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