UDP-GLUCURONOSYLTRANSFERASES - A FAMILY OF DETOXIFYING ENZYMES

被引：261

作者：

TEPHLY, TR ^{[1
]}

BURCHELL, B ^{[1
]}

机构：

[1] UNIV DUNDEE,NINEWELLS HOSP & MED SCH,DEPT BIOCHEM MED,DUNDEE DD1 9SY,SCOTLAND

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1990年 / 11卷 / 07期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0165-6147(90)90008-V

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Glucuronidation is an important process in the metabolism of xenobiotic and endogenous substances leading to enhancement of excretion of these compounds from the body. A multigene family encodes a number of UDP-glucuronosyltransferase enzymes which catalyse this route of metabolism. Recent advances in biochemical and molecular biological approaches, reviewed here by Thomas Tephly and Brian Burchell, have given new insight into the function and structure of UDP-glucuronosyltransferases. These proteins have surprising similarities and yet appear to be capable of conjugating a remarkable number of different chemicals. © 1990.

引用

页码：276 / 279

页数：4

共 26 条

[11] MACKENZIE P, 1990, J BIOL CHEM, V256, P3432
[12] MACKENZIE PI, 1986, J BIOL CHEM, V261, P6119
[13] SEPARATION OF DIFFERENT UDP GLUCURONOSYLTRANSFERASE ACTIVITIES ACCORDING TO CHARGE HETEROGENEITY BY CHROMATOFOCUSING USING MOUSE-LIVER MICROSOMES - 3 MAJOR TYPES OF AGLYCONES
MACKENZIE, PI
JOFFE, MM
MUNSON, PJ
OWENS, IS
[J]. BIOCHEMICAL PHARMACOLOGY, 1985, 34 (06) : 737 - 746
[14] SHORT CYTOPLASMIC SEQUENCES SERVE AS RETENTION SIGNALS FOR TRANSMEMBRANE PROTEINS IN THE ENDOPLASMIC-RETICULUM
NILSSON, T
JACKSON, M
PETERSON, PA
[J]. CELL, 1989, 58 (04) : 707 - 718
[15] PUIG JF, 1986, MOL PHARMACOL, V33, P97
[16] RANE A, 1986, ADV PAIN RES THER, V8, P57
[17] MECHANISMS FOR THE INCORPORATION OF PROTEINS IN MEMBRANES AND ORGANELLES
SABATINI, DD
KREIBICH, G
MORIMOTO, T
ADESNIK, M
[J]. JOURNAL OF CELL BIOLOGY, 1982, 92 (01) : 1 - 22
[18] STRUCTURAL REQUIREMENTS IN REACTION OF MORPHINE URIDINE-DIPHOSPHATE GLUCURONYLTRANSFERASE WITH OPIOID SUBSTANCES
SANCHEZ, E
DELVILLAR, E
TEPHLY, TR
[J]. BIOCHEMICAL JOURNAL, 1978, 169 (01) : 173 - 177
[19] SCRAGG I, 1985, ADV GLUCURONIDE CONJ, P390
[20] AN INVESTIGATION OF THE TRANSVERSE TOPOLOGY OF BILIRUBIN UDP-GLUCURONOSYLTRANSFERASE IN RAT HEPATIC ENDOPLASMIC-RETICULUM
SHEPHERD, SRP
BAIRD, SJ
HALLINAN, T
BURCHELL, B
[J]. BIOCHEMICAL JOURNAL, 1989, 259 (02) : 617 - 620

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