GENETIC-CONTROL OF IMMUNITY TO TRICHINELLA-SPIRALIS IN MICE - RESPONSE OF RAPID-RESPONDER AND SLOW-RESPONDER STRAINS TO IMMUNIZATION WITH PARASITE ANTIGENS

被引：15

作者：

WAKELIN, D ^{[1
]}

MITCHELL, LA ^{[1
]}

DONACHIE, AM ^{[1
]}

GRENCIS, RK ^{[1
]}

机构：

[1] UNIV NOTTINGHAM, DEPT ZOOL, MRC, EXPTL PARASITOL RES GRP, NOTTINGHAM NG7 2RD, ENGLAND

来源：

PARASITE IMMUNOLOGY | 1986年 / 8卷 / 02期

关键词：

D O I：

10.1111/j.1365-3024.1986.tb00842.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Slow-responder C57BL/10 (B10) mice responded poorly to immunization with muscle larval antigen of Trichinella spiralis showing no accelerated loss of worms from a subsequent challenge infection. In contrast, rapid-responder NIH mice and (B10 .times. NIH) F1 mice developed high levels of immunity after immunization. Lymphocyte proliferation studies showed that immunized B10 mice did respond to in vitro restimulation with antigen, though less well than NIH mice. Failure of B10 mice to respond to immunization did not therefore reflect a failure to recognize larval antigen, a view confirmed by the fact that immunization was achieved using abbreviated enteral infections and, to a smaller extent, by parenterally administered muscle larvae.

引用

页码：159 / 170

页数：12

共 31 条

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