RESISTANCE TO ANTIVIRAL INHIBITORS CAUSED BY THE MUTATION S889A IN THE HIGHLY-CONSERVED 885-GDTDS MOTIF OF THE HERPES-SIMPLEX VIRUS TYPE-1 DNA-POLYMERASE

被引：9

作者：

DORSKY, DI

PLOURDE, C

机构：

[1] Division of Infectious Diseases, Univ. of Connecticut Health Center, Farmington

来源：

VIROLOGY | 1993年 / 195卷 / 02期

关键词：

D O I：

10.1006/viro.1993.1439

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Most point substitutions in the highly-conserved 885-GDTDS motif of the HSV-1 DNA polymerase inactivate polymerase elongation activity. However, in an assay system based on expression by in vitro to transcription-translation, the mutant GDTDA (S889A) possessed wild-type elongation activity which was highly resistant to phosphonoacetic acid and acyclovir triphosphate, but retained sensitivity to aphidicolin. © 1993 Academic Press. All rights reserved.

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页码：831 / 835

页数：5

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