PENAZETIDINE-A, AN ALKALOID INHIBITOR OF PROTEIN-KINASE-C

被引：55

作者：

ALVI, KA

JASPARS, M

CREWS, P

STRULOVICI, B

OTO, E

机构：

[1] UNIV CALIF SANTA CRUZ,DEPT CHEM & BIOCHEM,SANTA CRUZ,CA 95064

[2] UNIV CALIF SANTA CRUZ,INST MARINE SCI,SANTA CRUZ,CA 95064

[3] SYNTEX INC,INST BIOCHEM & CELL BIOL,PALO ALTO,CA 94303

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 20期

关键词：

D O I：

10.1016/S0960-894X(01)80407-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The Indo-Pacific marine sponge Penares sollasi yielded a new protein kinase C inhibitor, penazetidine A (3). The structure of this compound was determined by spectroscopic data, including 1D and 2D NMR measurements as well as tandem mass spectrometry.

引用

页码：2447 / 2450

页数：4

共 18 条

[1] HIGH-PRESSURE-PROMOTED (2 + 2) CYCLOADDITIONS OF IMINES WITH ELECTRON-RICH ALKENES - A SIMPLE ROUTE TO AZETIDINES AND BETA-AMINO CARBONYL-COMPOUNDS
ABEN, RWM
SMIT, R
SCHEEREN, JW
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (03) : 365 - 370
[2] PROTEIN-TYROSINE KINASE INHIBITORY PROPERTIES OF PLANAR POLYCYCLICS OBTAINED FROM THE MARINE SPONGE XESTOSPONGIA CF CARBONARIA AND FROM TOTAL SYNTHESIS
ALVI, KA
RODRIGUEZ, J
DIAZ, MC
MORETTI, R
WILHELM, RS
LEE, RH
SLATE, DL
CREWS, P
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (18) : 4871 - 4880
[3] BALCH B, 1978, EXPERIENTIA, V34, P688
[4] PENASTEROL, A NOVEL ANTILEUKEMIC STEROL FROM THE OKINAWAN MARINE SPONGE PENARES SP
CHENG, JF
KOBAYASHI, J
NAKAMURA, H
OHIZUMI, Y
HIRATA, Y
SASAKI, T
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1988, (08): : 2403 - 2406
[5] K252A IS A POTENT AND SELECTIVE INHIBITOR OF PHOSPHORYLASE-KINASE
ELLIOTT, LH
WILKINSON, SE
SEDGWICK, AD
HILL, CH
LAWTON, G
DAVIS, PD
NIXON, JS
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 171 (01) : 148 - 154
[6] THE SEARCH FOR INOSINE 5'-PHOSPHATE DEHYDROGENASE (IMPDH) INHIBITORS FROM MARINE SPONGES - EVALUATION OF THE BASTADIN ALKALOIDS
JASPARS, M
RALI, T
LANEY, M
SCHATZMAN, RC
DIAZ, MC
SCHMITZ, FJ
PORDESIMO, EO
CREWS, P
[J]. TETRAHEDRON, 1994, 50 (25) : 7367 - 7374
[7] FAST-ATOM-BOMBARDMENT AND TANDEM MASS-SPECTROMETRY FOR DETERMINING ISO-FATTY AND ANTEISO-FATTY ACIDS
JENSEN, NJ
GROSS, ML
[J]. LIPIDS, 1986, 21 (05) : 362 - 365
[8] 11-HYDROXYSTAUROSPORINE - A HIGHLY CYTOTOXIC, POWERFUL PROTEIN-KINASE-C INHIBITOR FROM A TUNICATE
KINNEL, RB
SCHEUER, PJ
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (23) : 6327 - 6329
[9] PENARESIN, A NEW SARCOPLASMIC-RETICULUM CA-INDUCER FROM THE OKINAWAN MARINE SPONGE PENARES SP
KOBAYASHI, J
CHENG, JF
YAMAMURA, S
SASAKI, T
OHIZUMI, Y
[J]. HETEROCYCLES, 1990, 31 (12) : 2205 - 2208
[10] PENARESIDIN-A AND PENARESIDIN-B, 2 NOVEL AZETIDINE ALKALOIDS WITH POTENT ACTOMYOSIN ATPASE-ACTIVATING ACTIVITY FROM THE OKINAWAN MARINE SPONGE PENARES SP
KOBAYASHI, J
CHENG, J
ISHIBASHI, M
WALCHLI, MR
YAMAMURA, S
OHIZUMI, Y
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1991, (05): : 1135 - 1137

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