EFFECT OF CV-3988, A SPECIFIC ANTAGONIST AGAINST PLATELET ACTIVATING FACTOR, ON HOMOLOGOUS PASSIVE CUTANEOUS ANAPHYLAXIS IN THE MOUSE EAR

被引:11
作者
INAGAKI, N
MIURA, T
OHIRA, K
NAGAI, H
XU, Q
KODA, A
机构
[1] Department of Pharmacology, Gifu Pharmaceutical University, Gifu 502
来源
JOURNAL OF PHARMACOBIO-DYNAMICS | 1990年 / 13卷 / 05期
关键词
CV-3988; PAF antagonist; passive cutaneous anaphylaxis (PCA); platelet activating factor (PAF);
D O I
10.1248/bpb1978.13.272
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Effect of CV-3988, a specific antagonist against platelet activating factor (PAF), on homologous passive cutaneous anaphylaxis (PCA) elicited in the mouse ear was investigated. PAF caused a potent increase in vascular permeability in the mouse ear. The potency was slightly lower than that of serotonin but higher than those of histamine, leukotriene (LT) C4, LTD4, prostaglandin (PG) E1 and PGE2 on a weight basis. The increased vascular permeability caused by PAF was inhibited by CV-3988 in a dose-dependent manner. CV-3988 did not affect the increase in vascular permeability caused by histamine or serotonin. IgG1 antibody-mediated PCA in the mouse ear was inhibited by CV-3988, although it did not affect IgE antibody-mediated PCA. These results suggest a possibility that PAF might be involved in IgG1 antibody-mediated PCA in the mouse. © 1990, The Pharmaceutical Society of Japan. All rights reserved.
引用
收藏
页码:272 / 277
页数:6
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