MOLECULAR-PROPERTIES OF A SUPERFAMILY OF PLASMA-MEMBRANE CATION CHANNELS

被引：38

作者：

CATTERALL, WA

机构：

[1] University of Washington, Seattle

来源：

CURRENT OPINION IN CELL BIOLOGY | 1994年 / 6卷 / 04期

关键词：

D O I：

10.1016/0955-0674(94)90083-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The principal subunits of a large superfamily of plasma-membrane cation channels are functionally autonomous in ion conductance and in gating by membrane potential and intracellular ligands. Recent work has located the structural elements responsible for the ion conductance and gating of these channels. These studies reveal strong functional analogies among the different ion channels and suggest that the striking differences in their properties arise as variations on a common structural and functional theme.

引用

收藏

页码：607 / 615

页数：9

相关论文

共 63 条

[51] THE S4-S5 LOOP CONTRIBUTES TO THE ION-SELECTIVE PORE OF POTASSIUM CHANNELS [J].

SLESINGER, PA ;

JAN, YN ;

JAN, LY .

NEURON, 1993, 11 (04) :739-749

[52] IDENTIFICATION OF A PHENYLALKYLAMINE BINDING REGION WITHIN THE ALPHA-1 SUBUNIT OF SKELETAL-MUSCLE CA-2+ CHANNELS [J].

STRIESSNIG, J ;

GLOSSMANN, H ;

CATTERALL, WA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (23) :9108-9112

[53] STRUCTURAL PARTS INVOLVED IN ACTIVATION AND INACTIVATION OF THE SODIUM-CHANNEL [J].

STUHMER, W ;

CONTI, F ;

SUZUKI, H ;

WANG, XD ;

NODA, M ;

YAHAGI, N ;

KUBO, H ;

NUMA, S .

NATURE, 1989, 339 (6226) :597-603

[54]

TANG SQ, 1993, J BIOL CHEM, V268, P13026

[55] MAPPING THE SITE OF BLOCK BY TETRODOTOXIN AND SAXITOXIN OF SODIUM CHANNEL-II [J].

TERLAU, H ;

HEINEMANN, SH ;

STUHMER, W ;

PUSCH, M ;

CONTI, F ;

IMOTO, K ;

NUMA, S .

FEBS LETTERS, 1991, 293 (1-2) :93-96

[56]

TYTGAT J, 1993, J BIOL CHEM, V268, P23777

[57] INHIBITION OF INACTIVATION OF SINGLE SODIUM-CHANNELS BY A SITE-DIRECTED ANTIBODY [J].

VASSILEV, P ;

SCHEUER, T ;

CATTERALL, WA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (20) :8147-8151

[58] IDENTIFICATION OF AN INTRACELLULAR PEPTIDE SEGMENT INVOLVED IN SODIUM-CHANNEL INACTIVATION [J].

VASSILEV, PM ;

SCHEUER, T ;

CATTERALL, WA .

SCIENCE, 1988, 241 (4873) :1658-1661

[59] A CLUSTER OF HYDROPHOBIC AMINO-ACID-RESIDUES REQUIRED FOR FAST NA+-CHANNEL INACTIVATION [J].

WEST, JW ;

PATTON, DE ;

SCHEUER, T ;

WANG, YL ;

GOLDIN, AL ;

CATTERALL, WA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (22) :10910-10914

[60] MOLECULAR DETERMINANTS OF CA2+ SELECTIVITY AND ION PERMEATION IN L-TYPE CA2+ CHANNELS [J].

YANG, J ;

ELLINOR, PT ;

SATHER, WA ;

ZHANG, JF ;

TSIEN, RW .

NATURE, 1993, 366 (6451) :158-161

← 1 2 3 4 5 6 7 →