DISTRIBUTIONS OF NITROPYRENES AND MUTAGENICITY IN AIRBORNE-PARTICULATES COLLECTED WITH AN ANDERSEN SAMPLER

被引：49

作者：

HAYAKAWA, K

KAWAGUCHI, Y

MURAHASHI, T

MIYAZAKI, M

机构：

[1] Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, 920

来源：

MUTATION RESEARCH LETTERS | 1995年 / 348卷 / 02期

关键词：

AIRBORNE PARTICULATE; ANDERSEN SAMPLER; MUTAGENICITY; 1,3-DINITROPYRENE; 1,6-DINITROPYRENE; 1,8-DINITROPYRENE; 1-NITROPYRENE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC);

D O I：

10.1016/0165-7992(95)00046-1

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Distributions of 1,3-dinitropyrene (1,3-DNP), 1,6-DNP, 1,8-DNP, 1-nitropyrene (1-NP) and mutagenicity in airborne particulates collected in downtown Kanazawa, Japan with an Andersen high-volume air sampler were examined. Mutagenicities of benzene-ethanol extract from particulates were determined by the Ames test using S. typhimurium strains without 89 mix, while concentrations of DNPs and 1-NP were determined by high-performance liquid chromatography (HPLC) using chemiluminescence detection. In the finest particulate fraction (smaller than 1.1 mu m), 68% and 75% of the total mutagenicities were observed in TA98 and YG1024 strains, respectively. In the same fraction, 65-82% of three DNPs as well as 84% of 1-NP were observed. Mutagenic contributions of 1,3-DNP, 1,6-DNP, 1,8-DNP and 1-NP in the extract were respectively 0.6, 1.2, 1.8 and 1.6% in the TA98 strain, and 2.5, 5, 9 and 2.1% in the YG1024 strain.

引用

页码：57 / 61

页数：5

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