REGIONAL DIFFERENCES IN THE EFFECTS OF FORCED SWIMMING ON EXTRACELLULAR LEVELS OF 5-HYDROXYTRYPTAMINE AND 5-HYDROXYINDOLEACETIC ACID

被引：186

作者：

KIRBY, LG

ALLEN, AR

LUCKI, I

机构：

[1] UNIV PENN,INST NEUROL SCI,DEPT PSYCHIAT,PHILADELPHIA,PA 19104

[2] UNIV PENN,INST NEUROL SCI,DEPT PHARMACOL,PHILADELPHIA,PA 19104

来源：

BRAIN RESEARCH | 1995年 / 682卷 / 1-2期

关键词：

SEROTONIN; STRESSOR; MICRODIALYSIS; STRIATUM; HIPPOCAMPUS; CORTEX; AMYGDALA; SEPTUM;

D O I：

10.1016/0006-8993(95)00349-U

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of forced swimming for 30 min on extracellular 5-hydroxytryptamine (5-HT) levels were examined in five brain regions in rats using in vivo microdialysis. A single dialysis probe was implanted under surgical anesthesia into either the striatum, ventral hippocampus, frontal cortex, amygdala, or lateral septum on the day before the study. Dialysate content of 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) was measured by HPLC. Forced swimming elevated extracellular levels of 5-HT in the striatum to a maximum of 90% above baseline. In contrast, forced swimming reduced 5-HT levels in the amygdala and lateral septum to 50 and 40% of baseline, respectively. In the hippocampus and frontal cortex, 5-HT levels were not altered significantly by forced swimming. In all five brain regions, forced swimming reduced 5-HIAA levels to 45-60% of baseline. These results suggest that forced swimming modulates 5-HT neurotransmission in a regionally specific manner. Aside from being a significant biological stressor, the forced swimming test is used as an animal behavioral model to detect antidepressant drugs, including drugs that alter 5-HT neurotransmission. It is possible that the alterations of extracellular levels of 5-HT produced by forced swimming in certain brain regions may be associated with the ability of antidepressant drugs to selectively alter behavioral performance during the forced swimming test.

引用

页码：189 / 196

页数：8

共 35 条

[21] Lee, Lin, Yin, Differential influences of different stressors upon midbrain raphéneurons in rats, Brain Res., 470, (1987)
[22] Lucki, Singh, Kreiss, Antidepressant-like behavioral effects of serotonin receptor agonists, Neurosci. Biobehav. Rev., 18, pp. 85-95, (1994)
[23] Mitchell, Thomas, Effect of restraint stress and anxiolytics on 5-HT turnover in rat brain, Pharmacology, 37, pp. 105-113, (1988)
[24] Morgan, Rudeen, Pfeil, Effect of immobilization stress on serotonin content and turnover in regions of the rat brain, Life Sci., 17, pp. 143-150, (1975)
[25] Paxinos, Watson, The Rat Brain in Stereotaxic Coordinates, (1986)
[26] Pol, Campmany, Gil, Armario, Behavioral and neurochemical changes in response to acute stressors: Influence of previous chronic exposure to immobilization, Pharmacol. Biochem. Behav., 42, pp. 407-412, (1992)
[27] Porsolt, Le Pichon, Jalfre, Depression: a new animal model sensitive to antidepressant treatments, Nature, 266, pp. 730-732, (1977)
[28] Porsolt, Anton, Blavet, Jalfre, Behavioural despair in rats: a new model sensitive to antidepressant treatments, Eur. J. Pharmacol., 47, pp. 379-391, (1978)
[29] Rossetti, Lai, Hmaidan, Gessa, Depletion of mesolimbic dopamine during behavioural despair: partial reversal by chronic imipramine, Eur. J. Pharmacol., 242, pp. 313-315, (1993)
[30] Schreiber, DeVry, Neuroanatomical basis for the antidepressant-like effects of the 5-HT<sub>1A</sub> receptor ahonist 8-OH-DPATA and ipsapirone in the rat forced swim test, Behav. Pharmacol., 4, pp. 625-636, (1993)

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