INTERACTION BETWEEN ASYMMETRIC SOLUTES AND SOLVENTS - DIAMIDES DERIVED FROM L-VALINE AS STATIONARY PHASES IN GAS-LIQUID PARTITION CHROMATOGRAPHY

The resolution of enantiomers of (.+-.)-.alpha.-amino acids derivatives on optically active diamides derived from L-valine, R1CONHCH[CH(CH3)2]CONHR2, as gas chromatographic stationary phases was studied. The effects of the structure of R1 and R2 in the stationary phases, the structure of the racemic .alpha.-amino acid derivatives, temperature, etc., on the separation factors reported. In the light of these and related results, a more probable mechanism of resolution is presented.