AN INFECTIOUS MOLECULAR CLONE OF AN UNUSUAL MACROPHAGE-TROPIC AND HIGHLY CYTOPATHIC STRAIN OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1

被引：339

作者：

COLLMAN, R

BALLIET, JW

GREGORY, SA

FRIEDMAN, H

KOLSON, DL

NATHANSON, N

SRINIVASAN, A

机构：

[1] UNIV PENN,SCH MED,DEPT NEUROL,PHILADELPHIA,PA 19104

[2] UNIV PENN,SCH MED,DEPT MICROBIOL,PHILADELPHIA,PA 19104

[3] UNIV PENN,SCH MED,DEPT MED,DIV INFECT DIS,PHILADELPHIA,PA 19104

[4] WISTAR INST,PHILADELPHIA,PA 19104

来源：

JOURNAL OF VIROLOGY | 1992年 / 66卷 / 12期

关键词：

D O I：

10.1128/JVI.66.12.7517-7521.1992

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We isolated and molecularly cloned a human immunodeficiency virus type 1 (HIV-1) strain (89.6) which is unusual because it is both macrophage-tropic and extremely cytopathic in lymphocytes. Moreover, this is the first well-characterized infectious molecularly cloned macrophage-tropic HIV-1 strain derived from peripheral blood. HIV-1 89.6 differs markedly from other macrophage-tropic isolates within the envelope V3 region, which is important in determining cell tropism and cytopathicity. HIV-1 89.6 may thus represent a transitional isolate between noncytopathic macrophage-tropic viruses and cytopathic lymphocyte-tropic viruses.

引用

页码：7517 / 7521

页数：5

共 28 条

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