CHROMATOGRAPHIC DETERMINATION OF THE RADIOCHEMICAL PURITY OF [I-131] METAIODOBENZYLGUANIDINE INFUSION FLUIDS - A COMPARISON AND DISCUSSION OF THE CHROMATOGRAPHIC CHARACTERISTICS USING 3 DIFFERENT TECHNIQUES

被引：15

作者：

WAFELMAN, AR ^{[1
]}

HOEFNAGEL, CA ^{[1
]}

BEIJNEN, JH ^{[1
]}

机构：

[1] NETHERLANDS CANC INST,ANTONI VANLEEUWENHOEK HOSP,DEPT NUCL MED,1066 CX AMSTERDAM,NETHERLANDS

来源：

APPLIED RADIATION AND ISOTOPES | 1993年 / 44卷 / 05期

关键词：

D O I：

10.1016/0969-8043(93)90029-A

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

This paper proposes a reproducible and validated assay based on solid phase extraction for the determination of the level of free [I-131]iodide in [I-131]metaiodobenzylguanidine infusion fluids. The method has been compared with HPLC and TLC assays. Furthermore, a TLC system is introduced that allows the separation between metaiodobenzylguanidine, its chemical precursor metaiodobenzylamine and iodide. Attention is paid to the chromatographic characteristics of the analytes, with a discussion of the possible retention mechanisms.

引用

页码：859 / 867

页数：9

共 29 条

[11] RADIONUCLIDE THERAPY REVISITED [J].

HOEFNAGEL, CA .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 1991, 18 (06) :408-431

[12]

HOEFNAGEL CA, 1989, THESIS U AMSTERDAM

[13] METAIODOBENZYLGUANIDINE (MLBG) IN TREATMENT OF 47 PATIENTS WITH NEUROBLASTOMA - RESULTS OF THE GERMAN NEUROBLASTOMA TRIAL [J].

KLINGEBIEL, T ;

BERTHOLD, F ;

TREUNER, J ;

SCHWABE, D ;

FISCHER, M ;

FEINE, U ;

MAUL, FD ;

WATERS, W ;

WEHINGER, H ;

NIETHAMMER, D .

MEDICAL AND PEDIATRIC ONCOLOGY, 1991, 19 (02) :84-88

[14] USE OF M-[I-131]IODOBENZYLGUANIDINE IN THE TREATMENT OF MALIGNANT PHEOCHROMOCYTOMA [J].

KREMPF, M ;

LUMBROSO, J ;

MORNEX, R ;

BRENDEL, AJ ;

WEMEAU, JL ;

DELISLE, MJ ;

AUBERT, B ;

CARPENTIER, P ;

FLEURYGOYON, MC ;

GIBOLD, C ;

GUYOT, M ;

LAHNECHE, B ;

MARCHANDISE, X ;

SCHLUMBERGER, M ;

CHARBONNEL, B ;

CHATAL, JF .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1991, 72 (02) :455-461

[15] SOLID-PHASE EXCHANGE RADIOIODINATION OF ARYL IODIDES - FACILITATION BY AMMONIUM-SULFATE [J].

MANGNER, TJ ;

WU, JL ;

WIELAND, DM .

JOURNAL OF ORGANIC CHEMISTRY, 1982, 47 (08) :1484-1488

[16]

Mangner TJ., 1986, ANALYTICAL CHROMATOG, P261, DOI [10.1007/978-1-4612-4854-5_13, DOI 10.1007/978-1-4612-4854-5_13]

[17] RADIOIODINATED IODOBENZYLGUANIDINES FOR DIAGNOSIS AND THERAPY [J].

MCEWAN, AJ ;

WYETH, P ;

ACKERY, D .

APPLIED RADIATION AND ISOTOPES, 1986, 37 (08) :765-775

[18]

NAKAJO M, 1986, J NUCL MED, V27, P84

[19]

SAHA GB, 1983, FUNDAMENTALS NUCLEAR

[20] RADIOCHEMICAL DIAGNOSIS OF ADRENAL DISEASE [J].

SHAPIRO, B ;

FIG, LM ;

GROSS, MD ;

KHAFAGI, F .

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 1989, 27 (03) :265-298

← 1 2 3 →