THE EFFECTS OF A PURIFIED DIET ON SISTER CHROMATID EXCHANGE FREQUENCIES AND MITOTIC-ACTIVITY IN ADULT-RAT HEPATOCYTES

被引：15

作者：

ECKL, PM

ALATI, T

JIRTLE, RL

机构：

[1] SALZBURG UNIV,DIV GENET & DEV BIOL,A-5020 SALZBURG,AUSTRIA

[2] ELI LILLY & CO,DEPT M-7R1,INDIANAPOLIS,IN 46285

[3] ELI LILLY & CO,,INDIANAPOLIS,IN 46285

[4] DUKE UNIV,DEPT RADIOL,DURHAM,NC 27710

来源：

CARCINOGENESIS | 1991年 / 12卷 / 04期

关键词：

D O I：

10.1093/carcin/12.4.643

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

When female Fischer 344 rats were fed a commercial diet (Purina Rodent Laboratory Chow 5010) the background sister chromatid exchange (SCE) level in hepatocytes significantly increased with time, whereas feeding a purified diet (TEKLAD TD 81050) led to no significant changes in the SCE frequency. These results are consistent with the hypothesis that the dietary intake of mutagens/carcinogens causes an 'age-dependent' increase in hepatocyte SCE frequency. However, the high level of SCE found at the beginning of the experiment appears also to result from factors that are independent of the diet. Possible explanations include the relatively long cell cycle in hepatocytes and their sensitivity to lipid peroxidation products.

引用

页码：643 / 646

页数：4

共 36 条

[11] INDUCTION OF SISTER CHROMATID EXCHANGES IN CULTURED ADULT-RAT HEPATOCYTES BY DIRECTLY AND INDIRECTLY ACTING MUTAGENS CARCINOGENS [J].