DOPAMINE UPTAKE INHIBITORS BLOCK LONG-TERM NEUROTOXIC EFFECTS OF METHAMPHETAMINE UPON DOPAMINERGIC-NEURONS

被引：120

作者：

MAREK, GJ ^{[1
]}

VOSMER, G ^{[1
]}

SEIDEN, LS ^{[1
]}

机构：

[1] UNIV CHICAGO,DEPT PHARMACOL & PHYSIOL SCI,947 E 58TH ST,CHICAGO,IL 60637

来源：

BRAIN RESEARCH | 1990年 / 513卷 / 02期

关键词：

Amfonelic acid; Dopamine uptake inhibitor; Mazindol; Methamphetamine; Neurotoxicity;

D O I：

10.1016/0006-8993(90)90467-P

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A single large dose (100 mg/kg, s.c.) of methamphetamine (MA) is known to exert neurotoxic effects on dopaminergic neurons. The potency at which a series of dopamine (DA) uptake inhibitors blocked MA-induced neostriatal depletions (amfonelic acid (AFA) ≫ mazindol (MAZ) ≥ bupropion (BUP) > benztropine (BENZ)) was similar to their potency at blocking 6-hydroxydopamine (6-OHDA) neurotoxicity in rats. Amfonelic acid was able to block long-term neostriatal DA depletions when given 8 h, but not 16 h, after a single large MA dose. These results suggest that an intact and functional DA uptake site is necessary for the development of MA-induced long-term DA depletions. © 1990.

引用

页码：274 / 279

页数：6

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