DOPAMINE UPTAKE INHIBITORS BLOCK LONG-TERM NEUROTOXIC EFFECTS OF METHAMPHETAMINE UPON DOPAMINERGIC-NEURONS

被引：120

作者：

MAREK, GJ ^{[1
]}

VOSMER, G ^{[1
]}

SEIDEN, LS ^{[1
]}

机构：

[1] UNIV CHICAGO,DEPT PHARMACOL & PHYSIOL SCI,947 E 58TH ST,CHICAGO,IL 60637

来源：

BRAIN RESEARCH | 1990年 / 513卷 / 02期

关键词：

Amfonelic acid; Dopamine uptake inhibitor; Mazindol; Methamphetamine; Neurotoxicity;

D O I：

10.1016/0006-8993(90)90467-P

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A single large dose (100 mg/kg, s.c.) of methamphetamine (MA) is known to exert neurotoxic effects on dopaminergic neurons. The potency at which a series of dopamine (DA) uptake inhibitors blocked MA-induced neostriatal depletions (amfonelic acid (AFA) ≫ mazindol (MAZ) ≥ bupropion (BUP) > benztropine (BENZ)) was similar to their potency at blocking 6-hydroxydopamine (6-OHDA) neurotoxicity in rats. Amfonelic acid was able to block long-term neostriatal DA depletions when given 8 h, but not 16 h, after a single large MA dose. These results suggest that an intact and functional DA uptake site is necessary for the development of MA-induced long-term DA depletions. © 1990.

引用

页码：274 / 279

页数：6

共 34 条

[21] FLUOXETINE INCREASES LONG-LASTING NEOSTRIATAL DOPAMINE DEPLETION AFTER ADMINISTRATION OF D-METHAMPHETAMINE AND D-AMPHETAMINE [J].

RICAURTE, GA ;

FULLER, RW ;

PERRY, KW ;

SEIDEN, LS ;

SCHUSTER, CR .

NEUROPHARMACOLOGY, 1983, 22 (10) :1165-1169

[22] DOPAMINE NERVE-TERMINAL DEGENERATION PRODUCED BY HIGH-DOSES OF METHYLAMPHETAMINE IN THE RAT-BRAIN [J].

RICAURTE, GA ;

GUILLERY, RW ;

SEIDEN, LS ;

SCHUSTER, CR ;

MOORE, RY .

BRAIN RESEARCH, 1982, 235 (01) :93-103

[23] LONG-TERM EFFECTS OF PARA CHLOROAMPHETAMINE ON TRYPTOPHAN HYDROXYLASE-ACTIVITY AND ON LEVELS OF 5-HYDROXYTRYPTAMINE AND 5-HYDROXYINDOLE ACETIC-ACID IN BRAIN [J].

SANDERSB.E ;

BUSHING, JA ;

SULSER, F .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1972, 20 (03) :385-388

[24]

SCHMIDT CJ, 1987, J PHARMACOL EXP THER, V240, P107

[25] FORMATION OF 6-HYDROXYDOPAMINE IN CAUDATE-NUCLEUS OF THE RAT-BRAIN AFTER A SINGLE LARGE DOSE OF METHYLAMPHETAMINE [J].

SEIDEN, LS ;

VOSMER, G .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1984, 21 (01) :29-31

[26]

SEIDEN LS, 1975, DRUG ALCOHOL DEPEN, V1, P215

[27] LONG-TERM DECREASES IN STRIATAL DOPAMINE, 3,4-DIHYDROXYPHENYLACETIC ACID, AND HOMOVANILLIC-ACID AFTER A SINGLE INJECTION OF AMPHETAMINE IN IPRINDOLE-TREATED RATS - TIME COURSE AND TIME-DEPENDENT INTERACTIONS WITH AMFONELIC ACID [J].

STERANKA, LR .

BRAIN RESEARCH, 1982, 234 (01) :123-136

[28] LONG-TERM EFFECTS OF CONTINUOUS EXPOSURE TO AMPHETAMINE ON BRAIN DOPAMINE CONCENTRATION AND SYNAPTOSOMAL UPTAKE IN MICE [J].

STERANKA, LR ;

SANDERSBUSH, E .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1980, 65 (04) :439-443

[29] CHRONIC AMPHETAMINE ADMINISTRATION DECREASES BRAIN TRYPTOPHAN-HYDROXYLASE ACTIVITY IN CATS [J].

TRULSON, ME ;

JACOBS, BL .

LIFE SCIENCES, 1980, 26 (05) :329-335

[30] METHAMPHETAMINE-INDUCED CHANGES IN BRAIN CATECHOLAMINES IN RATS AND GUINEA-PIGS [J].

WAGNER, GC ;

SEIDEN, LS ;

SCHUSTER, CR .

DRUG AND ALCOHOL DEPENDENCE, 1979, 4 (05) :435-438

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