CENTROMERE - HUB OF CHROMOSOMAL ACTIVITIES

被引：295

作者：

PLUTA, AF ^{[1
]}

MACKAY, AM ^{[1
]}

AINSZTEIN, AM ^{[1
]}

GOLDBERG, IG ^{[1
]}

EARNSHAW, WC ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV, SCH MED, DEPT CELL BIOL & ANAT, BALTIMORE, MD 21205 USA

来源：

SCIENCE | 1995年 / 270卷 / 5242期

关键词：

D O I：

10.1126/science.270.5242.1591

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Centromeres are the structures that direct eukaryotic chromosome segregation In mitosis and meiosis. There are two major classes of centromeres. Point centromeres, found in the budding yeasts, are compact loci whose constituent proteins are now beginning to yield to biochemical analysis. Regional centromeres, best described in the fission yeast Schizosaccharomyces pombe, encompass many kilobases of DNA and are packaged into heterochromatin. Their associated proteins are as yet poorly understood. In addition to providing the site for microtubule attachment, centromeres also have an important role in checkpoint regulation during mitosis.

引用

页码：1591 / 1594

页数：4

共 99 条

[81] NUCLEOSOME DEPLETION ALTERS THE CHROMATIN STRUCTURE OF SACCHAROMYCES-CEREVISIAE CENTROMERES
SAUNDERS, MJ
YEH, E
GRUNSTEIN, M
BLOOM, K
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (11) : 5721 - 5727
[82] CENTROMERES - AN INTEGRATED PROTEIN DNA COMPLEX REQUIRED FOR CHROMOSOME MOVEMENT
SCHULMAN, I
BLOOM, KS
[J]. ANNUAL REVIEW OF CELL BIOLOGY, 1991, 7 : 311 - 336
[83] MICROINJECTED KINETOCHORE ANTIBODIES INTERFERE WITH CHROMOSOME MOVEMENT IN MEIOTIC AND MITOTIC MOUSE OOCYTES
SIMERLY, C
BALCZON, R
BRINKLEY, BR
SCHATTEN, G
[J]. JOURNAL OF CELL BIOLOGY, 1990, 111 (04) : 1491 - 1504
[84] FEEDBACK-CONTROL OF THE METAPHASE-ANAPHASE TRANSITION IN SEA-URCHIN ZYGOTES - ROLE OF MALORIENTED CHROMOSOMES
SLUDER, G
MILLER, FJ
THOMPSON, EA
WOLF, DE
[J]. JOURNAL OF CELL BIOLOGY, 1994, 126 (01) : 189 - 198
[85] FACTORS REQUIRED FOR THE BINDING OF REASSEMBLED YEAST KINETOCHORES MICROTUBULES IN-VITRO
SORGER, PK
SEVERIN, FF
HYMAN, AA
[J]. JOURNAL OF CELL BIOLOGY, 1994, 127 (04) : 995 - 1008
[86] CENTROMERE DNA MUTATIONS INDUCE A MITOTIC DELAY IN SACCHAROMYCES-CEREVISIAE
SPENCER, F
HIETER, P
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (19) : 8908 - 8912
[87] A NOVEL EPIGENETIC EFFECT CAN ALTER CENTROMERE FUNCTION IN FISSION YEAST
STEINER, NC
CLARKE, L
[J]. CELL, 1994, 79 (05) : 865 - 874
[88] CENTROMERES OF THE FISSION YEAST SCHIZOSACCHAROMYCES-POMBE ARE HIGHLY VARIABLE GENETIC-LOCI
STEINER, NC
HAHNENBERGER, KM
CLARKE, L
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (08) : 4578 - 4587
[89] A MUTATION IN CSE4, AN ESSENTIAL GENE ENCODING A NOVEL CHROMATIN-ASSOCIATED PROTEIN IN YEAST, CAUSES CHROMOSOME NONDISJUNCTION AND CELL-CYCLE ARREST AT MITOSIS
STOLER, S
KEITH, KC
CURNICK, KE
FITZGERALDHAYES, M
[J]. GENES & DEVELOPMENT, 1995, 9 (05) : 573 - 586
[90] CEP3 ENCODES A CENTROMERE PROTEIN OF SACCHAROMYCES-CEREVISIAE
STRUNNIKOV, AV
KINGSBURY, J
KOSHLAND, D
[J]. JOURNAL OF CELL BIOLOGY, 1995, 128 (05) : 749 - 760

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