HUMAN MONOAMINE OXIDASE-A AND OXIDASE-B GENES EXHIBIT IDENTICAL EXON INTRON ORGANIZATION

被引：234

作者：

GRIMSBY, J ^{[1
]}

CHEN, K ^{[1
]}

WANG, LJ ^{[1
]}

LAN, NC ^{[1
]}

SHIH, JC ^{[1
]}

机构：

[1] UNIV SO CALIF,SCH PHARM,DEPT MOLEC PHARMAC & TOXICOL,1985 ZONAL AVE,LOS ANGELES,CA 90033

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 09期

关键词：

HUMAN MAOA AND MAOB GENES; GENOMIC ORGANIZATION;

D O I：

10.1073/pnas.88.9.3637

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Monoamine oxidases A and B [MAOA and MAOB; amine:oxygen oxidoreductase (deaminating) (flavin-containing), EC 1.4.3.4] play important roles in the metabolism of neuroactive, vasoactive amines and the Parkinsonism-producing neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Human MAOA and MAOB genes isolated from X chromosome-specific libraries span at least 60 kilobases, consist of 15 exons, and exhibit identical exon-intron organization. Exon 12 codes for the covalent FAD-binding-site and is the most conserved exon; the MAOA and MAOB exon 12 products share 93.9% peptide identity. These results suggest that MAOA and MAOB are derived from duplication of a common ancestral gene and provide insight on the structural/functional relationship of the enzyme products.

引用

页码：3637 / 3641

页数：5

共 37 条

[1] CDNA CLONING OF HUMAN-LIVER MONOAMINE OXIDASE-A AND OXIDASE-B - MOLECULAR-BASIS OF DIFFERENCES IN ENZYMATIC-PROPERTIES [J].

BACH, AWJ ;

LAN, NC ;

JOHNSON, DL ;

ABELL, CW ;

BEMBENEK, ME ;

KWAN, SW ;

SEEBURG, PH ;

SHIH, JC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (13) :4934-4938

[2]

BRRETHNACH R, 1981, ANN REV BIOCH, V50, P349

[3] INTRON EXON STRUCTURE OF THE HUMAN-GENE FOR THE MUSCLE ISOZYME OF GLYCOGEN-PHOSPHORYLASE [J].

BURKE, J ;

HWANG, P ;

ANDERSON, L ;

LEBO, R ;

GORIN, F ;

FLETTERICK, R .

PROTEINS-STRUCTURE FUNCTION AND GENETICS, 1987, 2 (03) :177-187

[4] INTERACTION OF "N-(2-NITRO-4-AZIDOPHENYL)-SEROTONIN WITH 2 TYPES OF MONOAMINE-OXIDASE IN RAT-BRAIN [J].

CHEN, S ;

SHIH, JC ;

XU, QP .

JOURNAL OF NEUROCHEMISTRY, 1984, 43 (06) :1680-1687

[5] 4-FLUORO-3-NITROPHENYL AZIDE, A SELECTIVE PHOTOAFFINITY LABEL FOR TYPE-B MONOAMINE-OXIDASE [J].

CHEN, S ;

SHIH, JC ;

XU, QP .

BIOCHEMICAL PHARMACOLOGY, 1985, 34 (06) :781-788

[6] METABOLISM OF THE NEUROTOXIC TERTIARY AMINE, MPTP, BY BRAIN MONOAMINE-OXIDASE [J].

CHIBA, K ;

TREVOR, A ;

CASTAGNOLI, N .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (02) :574-578

[7] HUMAN-LIVER MAO-A AND MAO-B SEPARATED BY IMMUNOAFFINITY CHROMATOGRAPHY WITH MAO-B-SPECIFIC MONOCLONAL-ANTIBODY [J].

DENNEY, RM ;

FRITZ, RR ;

PATEL, NT ;

ABELL, CW .

SCIENCE, 1982, 215 (4538) :1400-1403

[8] STUDIES ON MONOAMINE-OXIDASE .18. ENZYMIC PROPERTIES OF PLACENTAL MONOAMINE-OXIDASE [J].

EGASHIRA, T .

JAPANESE JOURNAL OF PHARMACOLOGY, 1976, 26 (04) :493-500

[9] A TECHNIQUE FOR RADIOLABELING DNA RESTRICTION ENDONUCLEASE FRAGMENTS TO HIGH SPECIFIC ACTIVITY [J].

FEINBERG, AP ;

VOGELSTEIN, B .

ANALYTICAL BIOCHEMISTRY, 1983, 132 (01) :6-13

[10] MONOAMINE-OXIDASE A AND B - USEFUL CONCEPT [J].

FOWLER, CJ ;

CALLINGHAM, BA ;

MANTLE, TJ ;

TIPTON, KF .

BIOCHEMICAL PHARMACOLOGY, 1978, 27 (01) :97-101

← 1 2 3 4 →