DIAZEPAM ANTAGONIZES EFFECTS ON DOPAMINE METABOLISM PRODUCED BY PCP RECEPTOR AGONISTS

被引：9

作者：

BOWERS, MB

MORTON, JB

机构：

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1992年 / 16卷 / 02期

关键词：

DIAZEPAM; DOPAMINE; HOMOVANILLIC ACID (HVA); MK-801; PCP;

D O I：

10.1016/0278-5846(92)90072-M

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. Male rats were injected with either saline, diazepam, MK-801, or diazepam plus MK-801. 2. In previous work with phencyclidine (PCP), diazepam significantly reduced the increase in homovanillic acid (HVA) in olfactory tubercle and prefrontal cortex. 3. Diazepam also lowered the HVA increase following MK-801 in caudate, olfactory tubercle, and prefrontal cortex. 4. Benzodiazepine receptors may modify dopaminergic function at PCP receptors that affect dopamine neurotransmission.

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页码：211 / 215

页数：5

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