HYDROLYSIS OF BENZODIAZEPINES IN A MICROWAVE-OVEN AND ULTRAVIOLET DERIVATIVE ANALYSIS OF THEIR BENZOPHENONES

被引：7

作者：

MORALESRUBIO, A

JULIANORTIZ, JV

SALVADOR, A

DELAGUARDIA, M

机构：

[1] UNIV VALENCIA,DEPT ANALYT CHEM,50 DR MOLINER ST,E-46100 BURJASSOT,SPAIN

[2] UNIV VALENCIA,DEPT ORGAN CHEM,E-46100 BURJASSOT,SPAIN

来源：

MICROCHEMICAL JOURNAL | 1994年 / 49卷 / 01期

关键词：

D O I：

10.1006/mchj.1994.1003

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Oxazepam, clonazepam, lorazepam, nitrazepam, prazepam, and dipotassium chlorazepate have been quantitatively hydrolyzed in 6 M HCL to their respective benzophenones using a microwave oven with 520 W power and a digestion time of 8 mm. The hydrolysis yield obtained in each case corresponds to 103, 117, 98, 115, 97, and 97%, respectively. Chlorazepate has been used as a test molecule to evaluate the effect of the digestion parameters, such as power and digestion time, on the hydrolysis yield. To determine benzophenones in the presence of benzodiazepines, in order to establish the hydrolysis yield, derivative ultraviolet spectrometry has been employed, using the isodifferential approach. © 1994 Academic Press. All rights reserved.

引用

页码：12 / 19

页数：8