N-HYDROXYPYRIDINETHIONES AS PHOTOCHEMICAL HYDROXYL RADICAL SOURCES FOR OXIDATIVE DNA-DAMAGE

被引：52

作者：

ADAM, W ^{[1
]}

BALLMAIER, D ^{[1
]}

EPE, B ^{[1
]}

GRIMM, GN ^{[1
]}

SAHAMOLLER, CR ^{[1
]}

机构：

[1] UNIV WURZBURG,INST PHARMAKOL & TOXIKOL,D-97074 WURZBURG,GERMANY

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1995年 / 34卷 / 19期

关键词：

DNA OXIDATIONS; HYDROXYL RADICAL; N-HYDROXYPYRIDINETHIONE;

D O I：

10.1002/anie.199521561

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

On irradiation with UV light (λ = 350 nm) the N‐hydroxypridinethiones 1 and 2 generate hydroxyl radicals, which cause single‐strand breaks and base modifications in calf thymus DNA and superhelical PM2 DNA. The para isomer 2 is significantly more genotoxic than the known antibacterial and fungicidal reagent pyridinethione 1. (Figure Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：2156 / 2158

页数：3

共 27 条

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