THERMOREGULATORY ACTIVITY OF SODIUM-NITROPRUSSIDE AND ARGININE-VASOPRESSIN

被引：9

作者：

GAGALO, IT ^{[1
]}

HAC, EE ^{[1
]}

MATUSZEK, MT ^{[1
]}

REKOWSKI, P ^{[1
]}

KUPRYSZEWSKI, G ^{[1
]}

KOROLKIEWICZ, KZ ^{[1
]}

机构：

[1] UNIV GDANSK,FAC CHEM,PL-80952 GDANSK,POLAND

来源：

GENERAL PHARMACOLOGY | 1995年 / 26卷 / 02期

关键词：

SODIUM NITROPRUSSIDE; ARGININE VASOPRESSIN; THERMOREGULATORY RESPONSES; BLOOD PRESSURE;

D O I：

10.1016/0306-3623(94)00205-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Thermal responses to sodium nitroprusside (SNP, 3 mg/kg/hr) and arginine vasopressin (AVP, 3 mu g/kg) were investigated in normothermic and febrile rabbits (LPS, 1 mu g/kg) at ambient temperature of 20.0 +/- 1.0 degrees C. Furthermore, blood pressure after these drugs was tested on a separate group of animals. 2. I.V. infusion of SNP produced hypothermia and attenuated pyrogen fever. On the other hand, AVP increased body temperature and intensified the febrile response. 3. Both drugs affected in an opposite way blood pressure, i.e. SNP produced falls and AVP increases in this parameter. 4. The relationship between the activity of the vascular and thermoregulatory systems in normothermic or febrile state is discussed.

引用

页码：393 / 397

页数：5

共 16 条

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