HITHERTO UNRECOGNIZED ARTERIOLES WITHIN HEPATOCELLULAR-CARCINOMA

被引：32

作者：

HIMENO, H ^{[1
]}

ENZAN, H ^{[1
]}

SAIBARA, T ^{[1
]}

ONISHI, S ^{[1
]}

YAMAMOTO, Y ^{[1
]}

机构：

[1] KOCHI MED SCH,DEPT PATHOL 1,NANKO KU,KOCHI 783,JAPAN

来源：

JOURNAL OF PATHOLOGY | 1994年 / 174卷 / 03期

关键词：

D O I：

10.1002/path.1711740311

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The distribution of blood vessels in human hepatocellular carcinoma was studied with the anti-a-smooth muscle actin monoclonal antibody by light and electron microscopy, and with morphometric analysis. a-smooth muscle actin-positive arterioles were never observed in lobules or pseudolobules of non-cancerous areas, but were frequently seen within hepatocellular carcinomas. Morphometric analysis revealed that most of these arterioles measured between 10 and 25 mu m in diameter. The morphology of intratumoural arterioles differed considerably from that of conventional arteries in the portal tracts of the non-cancerous area. The presence of abundant intratumoural arterioles can explain the angiographic hypervascularity of hepatocellular carcinoma and provides a pathological basis for its susceptibility to hypoxia and for arterial embolization as a therapeutic strategy.

引用

页码：217 / 222

页数：6