ROLE OF BRUTONS TYROSINE KINASE IN IMMUNODEFICIENCY

被引：92

作者：

TSUKADA, S ^{[1
]}

RAWLINGS, DJ ^{[1
]}

WITTE, ON ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES, HOWARD HUGHES MED INST, LOS ANGELES, CA 90024 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1994年 / 6卷 / 04期

关键词：

D O I：

10.1016/0952-7915(94)90151-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The genetic defect associated with human X-linked agammaglobulinemia and murine X-linked immunodeficiency was recently shown to result from lack of function of a new cytoplasmic tyrosine kinase, called Bruton's tyrosine kinase (Btk). The phenotypes associated with these immunodeficiencies indicate that Btk plays a critical role in B-lymphocyte development. The distinctive protein structure of Btk and preliminary functional studies suggest that Btk may act in a novel manner in a variety of signaling pathways.

引用

页码：623 / 630

页数：8

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