ROLE OF BRUTONS TYROSINE KINASE IN IMMUNODEFICIENCY

被引：92

作者：

TSUKADA, S ^{[1
]}

RAWLINGS, DJ ^{[1
]}

WITTE, ON ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES, HOWARD HUGHES MED INST, LOS ANGELES, CA 90024 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1994年 / 6卷 / 04期

关键词：

D O I：

10.1016/0952-7915(94)90151-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The genetic defect associated with human X-linked agammaglobulinemia and murine X-linked immunodeficiency was recently shown to result from lack of function of a new cytoplasmic tyrosine kinase, called Bruton's tyrosine kinase (Btk). The phenotypes associated with these immunodeficiencies indicate that Btk plays a critical role in B-lymphocyte development. The distinctive protein structure of Btk and preliminary functional studies suggest that Btk may act in a novel manner in a variety of signaling pathways.

引用

页码：623 / 630

页数：8

共 71 条

[21] PLECKSTRIN DOMAIN HOMOLOGY [J].

HASLAM, RJ ;

KOIDE, HB ;

HEMMINGS, BA .

NATURE, 1993, 363 (6427) :309-310

[22] FUNCTIONAL INACTIVATION OF GENES BY DOMINANT NEGATIVE MUTATIONS [J].

HERSKOWITZ, I .

NATURE, 1987, 329 (6136) :219-222

[23] DEVELOPMENTAL REGULATION OF A MURINE T-CELL-SPECIFIC TYROSINE KINASE GENE, TSK [J].

HEYECK, SD ;

BERG, LJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (02) :669-673

[24]

HILLYARD AL, 1992, MOUSE GENOME, V90, P8

[25] IL-5 RECEPTOR-POSITIVE B-CELLS, BUT NOT EOSINOPHILS, ARE FUNCTIONALLY AND NUMERICALLY INFLUENCED IN MICE CARRYING THE X-LINKED IMMUNE DEFECT [J].

HITOSHI, Y ;

SONODA, E ;

KIKUCHI, Y ;

YONEHARA, S ;

NAKAUCHI, H ;

TAKATSU, K .

INTERNATIONAL IMMUNOLOGY, 1993, 5 (09) :1183-1190

[26] FC-EPSILON-RI-MEDIATED TYROSINE PHOSPHORYLATION AND ACTIVATION OF THE 72-KDA PROTEIN-TYROSINE KINASE, PTK72, IN RBL-2H3 RAT-TUMOR MAST-CELLS [J].

HUTCHCROFT, JE ;

GEAHLEN, RL ;

DEANIN, GG ;

OLIVER, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (19) :9107-9111

[27] SUBUNITS-BETA-GAMMA OF HETEROTRIMERIC G-PROTEIN ACTIVATE BETA-2 ISOFORM OF PHOSPHOLIPASE-C [J].

KATZ, A ;

WU, DQ ;

SIMON, MI .

NATURE, 1992, 360 (6405) :686-689

[28]

KAWAKAMI T, 1992, J IMMUNOL, V148, P3513

[29]

KINNON C, 1993, IMMUNOL TODAY, V14, P554, DOI 10.1016/0167-5699(93)90187-P

[30] CYTOKINE SIGNAL-TRANSDUCTION [J].

KISHIMOTO, T ;

TAGA, T ;

AKIRA, S .

CELL, 1994, 76 (02) :253-262

← 1 2 3 4 5 6 7 8 →