CHLAMYDOSPOROL, A NEW METABOLITE FROM FUSARIUM-CHLAMYDOSPORUM

被引：29

作者：

SAVARD, ME ^{[1
]}

MILLER, JD ^{[1
]}

SALLEH, B ^{[1
]}

STRANGE, RN ^{[1
]}

机构：

[1] UNIV LONDON UNIV COLL,DEPT BIOL,LONDON WC1E 6BT,ENGLAND

来源：

MYCOPATHOLOGIA | 1990年 / 110卷 / 03期

关键词：

Chlamydosporol; Fusarium chlamydosporum; mycotoxin;

D O I：

10.1007/BF00437543

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Extracts of rice on which an isolate of Fusarium chlamydosporum had been cultured were toxic to brine shrimps. The toxic fraction was purified by flash chromatography to give two compounds which were identified by UV, IR, NMR and mass spectroscopy at the 6 α and 6 β isomers of 5-hydroxy-4-methoxy-6, 8a-dimethyl-6,7-dihydro-2H,8aH-pyrano[2,3-b]pyran-2-one. These lactones for which the name chlamydosporol is proposed have not been reported previously. When tested in brine shrimp and HeLa cell assays, the LC50 concentration for a mixture of the isomers was approximately 400 μg/ml in both systems. © 1990 Kluwer Academic Publishers.

引用

页码：177 / 181

页数：5

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