ANTIFUNGAL AGENTS .5. CHLORO AND AMINO DERIVATIVES OF 1,2-DIARYL-1-(1H-IMIDAZOL-1-YL)ETHANE WITH POTENT ANTIFUNGAL ACTIVITIES

被引：10

作者：

ARTICO, M ^{[1
]}

MASSA, S ^{[1
]}

DISANTO, R ^{[1
]}

COSTI, R ^{[1
]}

RETICO, A ^{[1
]}

APUZZO, G ^{[1
]}

SIMONETTI, N ^{[1
]}

机构：

[1] UNIV ROMA LA SAPIENZA,FAC FARM,IST MICROBIOL,I-00185 ROME,ITALY

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1993年 / 28卷 / 09期

关键词：

ANTIFUNGAL AGENTS; ESTROGEN-LIKE IMIDAZOLES; 1,2-DIARYL-1-(1H-IMIDAZOL-1-YL)ETHANE DERIVATIVES;

D O I：

10.1016/0223-5234(93)90031-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Various derivatives of 1,2-diaryl-1-(1H-imidazol-1-yl)ethane have been synthesized and tested against Candida albicans and Candida spp. In vitro essays showed chloro and amino derivatives to be as active as miconazole and bifonazole and more potent than ketoconazole. Structure-activity relationships of the new imidazole antifungal agents are discussed.

引用

页码：715 / 720

页数：6

共 16 条

[1] RESEARCH ON ANTIBACTERIAL AND ANTIFUNGAL AGENTS .16. SYNTHESIS AND ANTIFUNGAL ACTIVITIES OF 1-[ALPHA-(1-NAPHTHYL)BENZYL]IMIDAZOLE DERIVATIVES AND RELATED 2-NAPHTHYL ISOMERS [J].

ARTICO, M ;

STEFANCICH, G ;

SILVESTRI, R ;

MASSA, S ;

APUZZO, G ;

ARTICO, M ;

SIMONETTI, G .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1992, 27 (07) :693-699

[2] ADDITION OF NITROTOLUENES TO ALDEHYDES [J].

BAKKE, J .

ACTA CHEMICA SCANDINAVICA, 1967, 21 (07) :1967-&

[3]

BAKKE J, 1969, Patent No. 1568656

[4]

BERTI G, 1961, ANN CHIM-ROME, V51, P675

[5] ELECTRON-IMPACT STUDIES - .101. - NEGATIVE-ION MASS-SPECTRA OF CARBONYL GROUP - ARYL-CH2-CO-AND ARYL-(CH2)2-CO-SYSTEMS [J].

BOWIE, JH ;

JANPOSRI, S .

ORGANIC MASS SPECTROMETRY, 1975, 10 (12) :1117-1124

[6] Mixed benzoins II [J].

Buck, JS ;

Ide, WS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1930, 52 :4107-4109

[7] PREPARATION OF CIS AND TRANS 2,5-DIMETHOXY-2-(ACETAMIDOMETHYL)-2,5-DIHYDROFURAN, OF CISS AND TRANS 2,5-DIMETHOXY-2-(ACETAMIDOMETHYL)-TETRAHYDROFURAN AND OF 1-PHENYL-2-(ACETAMIDOMETHYL)-PYRROLE [J].

CLAUSONKAAS, N ;

TYLE, Z .

ACTA CHEMICA SCANDINAVICA, 1952, 6 (05) :667-670

[8]

FROMTLING R A, 1984, Drugs of Today, V20, P325

[9]

Funasaka W., 1959, YUKI GOSEI KAGAKU KY, V17, P717

[10]

JENKINS SS, 1935, J AM CHEM SOC, V55, P3874

← 1 2 →