A NOVEL 4-AMINOBENZYL ESTER-BASED CARBOXY-PROTECTING GROUP FOR SYNTHESIS OF ATYPICAL PEPTIDES BY FMOC-BU(T) SOLID-PHASE CHEMISTRY

被引：66

作者：

CHAN, WC ^{[1
]}

BYCROFT, BW ^{[1
]}

EVANS, DJ ^{[1
]}

WHITE, PD ^{[1
]}

机构：

[1] CALBIOCHEM NOVABIOCHEM UK LTD,NOTTINGHAM NG9 2JR,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1995年 / 21期

关键词：

D O I：

10.1039/c39950002209

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

4-{N-[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}benzyl ester (ODmab) is a new carboxy-protecting group that is based on the safety-catch principle and can be used orthogonally with Fmoc-Bu(t) peptide chemistry, but is completely removable with 2% v/v hydrazine . H2O-DMF at room temperature within minutes.

引用

页码：2209 / 2210

页数：2

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