TOTAL SYNTHESIS OF THE THYMIDINE ANALOG OF SINEFUNGIN

被引：7

作者：

BARTON, DHR

GERO, SD

NEGRON, G

QUICLETSIRE, B

SAMADI, M

VINCENT, C

机构：

[1] CNRS,INST CHIM SUBST NAT,F-91198 GIF SUR YVETTE,FRANCE

[2] TEXAS A&M UNIV,DEPT CHEM,COLLEGE STN,TX 77843

[3] UNIV AUTONOMA METROPOLITANA AZCAPOTZALCO,AREA QUIM,MEXICO CITY 02200,DF,MEXICO

来源：

NUCLEOSIDES & NUCLEOTIDES | 1995年 / 14卷 / 08期

关键词：

D O I：

10.1080/15257779508009744

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The carbon skeleton of ''Sinethymidin'' 4 was constructed by two radical coupling reaction. The first step was a coupling of the radical derived from 2 and the unsaturated amide 5. The olefin 6 thus obtained was added to the radical derived from the known N-hydroxy-2-thiopyridinone aspartic ester. ''Sinethymidin'', tested for its antileismanial effect, was devoid of activity.

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页码：1619 / 1630

页数：12

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