CALCITONIN - FROM THE DETERMINATION OF CIRCULATING LEVELS IN VARIOUS PHYSIOLOGICAL AND PATHOLOGICAL CONDITIONS TO THE DEMONSTRATION OF LYMPHOCYTE RECEPTORS

被引:14
作者
BODY, JJ [1 ]
机构
[1] UNIV LIBRE BRUXELLES,CTR TUMEURS,INST JULES BORDET,INVEST LAB,CLIN HJ TAGNON,BRUSSELS,BELGIUM
关键词
BONE; CALCITONIN; ESTROGENS; HYPERPARATHYROIDISM; IMMUNOASSAY; LYMPHOCYTE; OSTEOCLAST; OSTEOPOROSIS; RECEPTOR; THYROID;
D O I
10.1159/000182719
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This article summarizes our main findings concerning calcitonin (CT) physiology and pathology. We have devised a simple extraction method of circulating CT that much improves assay sensitivity and specificity for the measurement of the CT monomer. Combining this extraction method with newer immunometric assays permits a sensitive and exclusive measurement of monomeric CT. CT secretory capacity is 4-5 times lower in women than in men, but there is no significant fall in basal or calcium-stimulated CT levels with age. We also found no evidence for CT deficiency in postmenopausal osteoporosis. On the contrary, changes in circulating CT levels appear to be secondary to the changes in bone turnover, whether in postmenopausal osteoporosis, after estrogen replacement therapy or in renal stone formers. We found a marked CT deficiency after thyroidectomy, radioactive iodine treatment and in patients with congenital hypothyroidism or autoimmune primary hypothyroidism. The deleterious effects of CT deficiency on bone mass remain, however, essentially speculative. Lastly, we have found specific and high-affinity CT receptors on normal circulating T-lymphocytes. Their meaning remains to be demonstrated but we have recently found that the osteolytic cytokines IL-1 and IL-6 are able to markedly reduce the number of CT receptors on T-lymphocytes without changing their affinity.
引用
收藏
页码:166 / 170
页数:5
相关论文
共 24 条
  • [21] EVIDENCE FOR AN IMPORTANT PHYSIOLOGICAL-ROLE FOR CALCITONIN
    TALMAGE, RV
    GRUBB, SA
    NORIMATSU, H
    VANDERWIEL, CJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (01): : 609 - 613
  • [22] CALCITONIN SECRETION IN POSTMENOPAUSAL OSTEOPOROSIS
    TIEGS, RD
    BODY, JJ
    WAHNER, HW
    BARTA, J
    RIGGS, BL
    HEATH, H
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1985, 312 (17) : 1097 - 1100
  • [23] PLASMA CALCITONIN IN PRIMARY HYPERPARATHYROIDISM - FAILURE OF C-CELL RESPONSE TO SUSTAINED HYPERCALCEMIA
    TIEGS, RD
    BODY, JJ
    BARTA, JM
    HEATH, H
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1986, 63 (03) : 785 - 788
  • [24] TIEGS RD, 1986, J BONE MINER RES, V1, P339