AMYLIN RELEASE FROM PERFUSED RAT PANCREAS IN RESPONSE TO GLUCOSE AND ARGININE

被引：21

作者：

INOUE, K

HISATOMI, A

UMEDA, F

NAWATA, H

机构：

[1] Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 1990年 / 10卷 / 02期

关键词：

Amylin; Glucose; Islet amyloid polypeptide; Pancreas perfusion;

D O I：

10.1016/0168-8227(90)90043-S

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of glucose and arginine on the release of amylin from the perfused rat pancreas were studied. Amylin, or islet amyloid polypeptide, is a 37-amino acid peptide isolated from pancreatic islet amyloid of patients with non-insulin-dependent diabetes mellitus (NIDDM). Glucose stimulated dose-dependently amylin release, showing a typical biphasic pattern. Additionally, 10 mM arginine in the presence of 5.5 mM glucose also stimulated amylin release. These findings suggest that amylin is a secretory protein and its release from the pancreas is regulated by glucose and other nutrients. © 1990.

引用

页码：189 / 192

页数：4

共 16 条

[11] PANCREATIC AMYLIN AND CALCITONIN GENE-RELATED PEPTIDE CAUSE RESISTANCE TO INSULIN IN SKELETAL-MUSCLE INVITRO [J].